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Cat. No.: HY-N18316

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(2"S)-6"-Methyl-2",3"-Dihydrodelicaflavone

(2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone exhibits antiproliferative activity against non-small cell lung cancer cells (IC₅₀ = 3.1-6.8 μM) with low cytotoxicity toward normal cells. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone can be used in studies related to non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 3035699-20-5
Formula: C₃₁H₂₂O₁₀
Molecular Weight:554.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(2"S)-6"-Methyl-2",3"-Dihydrodelicaflavone Chemical Structure

CAS No.: 3035699-20-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

(2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone (compound 4) (0-100 μM; 24 h) potently inhibits the proliferation of A549 and H1299 non-small cell lung cancer cells in vitro, and exhibits low cytotoxicity against normal MRC-5 lung cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

human non-small cell lung cancer A549 cells, human non-small cell lung cancer H1299 cells, human normal embryonic lung MRC-5 cells
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Potently inhibited proliferation of A549 cells with an IC₅₀ of 3.1 μM.
Inhibited proliferation of H1299 cells with an IC₅₀ of 6.8 μM.
Showed low toxicity to non-cancer MRC-5 cells with an IC₅₀ of 58.2 μM.

Chemical Information

CAS No. 3035699-20-5
Molecular Weight 554.50
Formula C₃₁H₂₂O₁₀
SMILES

O=C(C(OC1=CC=C([C@H]2OC3=CC(O)=C(C)C(O)=C3C(C2)=O)C=C1)=C(C4=CC=C(C=C4)O)OC5=CC(O)=C6)C5=C6O
Structure Classification
- Flavonoids
- Biflavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kang F, et al. Biflavonoids from Selaginella doederleinii as Potential Antitumor Agents for Intervention of Non-Small Cell Lung Cancer. Molecules. 2021 Sep 5;26(17):5401.
[Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(2"S)-6"-Methyl-2",3"-Dihydrodelicaflavone

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(2"S)-6"-Methyl-2",3"-Dihydrodelicaflavone

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

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(2"S)-6"-Methyl-2",3"-Dihydrodelicaflavone Related Classifications

HY-N18316 Related Classifications

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