ACE2-SP PPI-IN-1
ACE2-SP PPI-IN-1 is an inhibitor of the interaction between the SARS-CoV-2 spike protein and ACE2, with an IC50 of 2162.77 nM. ACE2-SP PPI-IN-1 exhibits low cytotoxicity in human fibroblasts. ACE2-SP PPI-IN-1 binds to the interface region between the spike protein RBD and ACE2, reducing the flexibility of the critical receptor-binding loop and maintaining the structural compactness of the spike protein. ACE2-SP PPI-IN-1 can be used for research related to SARS-CoV-2.
For research use only. We do not sell to patients.
- Formula: C21H18FN3OS
- Molecular Weight:379.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
ACE2-SP PPI-IN-1 (NS1) inhibits the SARS-CoV-2 spike S1 RBD-human ACE2 interaction in a cell-free biochemical assay with an IC50 of 2162.77 nM[1].
ACE2-SP PPI-IN-1 (30 μM; 48 h) shows low cytotoxicity in human BJ fibroblast cells, with 8.4% inhibition of cell viability at 30 μM after 48 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human BJ fibroblast cells
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Concentration:30 μM
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Incubation Time:48 h
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Result:Exhibited low cytotoxicity, with a mean percentage inhibition of cell viability of 8.4% after 48 h exposure at 30 μM.
Chemical Information
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Molecular Weight 379.45
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Formula C21H18FN3OS
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SMILES
COC1=CC2=CC=C(C=C2C=C1)C(C3=NN=C(S3)NC4=C(C=CC=C4)F)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)