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Cat. No.: HY-155734

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SARS-CoV-2-IN-55

SARS-CoV-2-IN-55(compound 65) is a low cytotoxicity inhibtor of SARS-CoV-2 with an IC₅₀ value of 0.3 μM, by the direct interaction with VSV-S pseudoparticles.

For research use only. We do not sell to patients.

Formula: C₁₃₈H₁₃₆N₂₂O₃₂S₆
Molecular Weight:2807.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

SARS-CoV-2-IN-55 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

SARS-CoV-2-IN-55(compound 65) is a low cytotoxicity inhibtor of SARS-CoV-2 with an IC₅₀ value of 0.3 μM, by the direct interaction with VSV-S pseudoparticles^[1].

IC₅₀ & Target

IC50: 0.3 μM (SARS-CoV-2)^[1]

In Vitro

SARS-CoV-2-IN-55 (10 μM, 24 h) inhibits the viral activity of SARS-CoV-2 in Vero E6 cell and A549-ACE2-TMPRSS2 cell respectively with the IC₅₀ value of 0.3 μM and 15.8 μM, meanwhile inhibits the viral activity of Wuhan-Hu-1 (IC₅₀=0.28 μM) and Omicron BA.1 (IC₅₀=6.24 μM) in Vero E6-TMPRSS2 cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiviral Activity assay

Cell Line:

Vero E6 , A549-Ace2-TMPRSS2 cell, Vero E6-TMPRSS2 Cell ^[1]
Concentration:

10 μM
Incubation Time:

24 h
Result:

Inhibted the viral activity of SARS-CoV-2 in Vero E6 and A549-Ace2-TMPRSS2 cell.
Inhibted the viral activity of Wuhan-Hu-1 and Omicron BA.1 in Vero E6-TMPRSS2 Cell.

Chemical Information

Molecular Weight 2807.07
Formula C₁₃₈H₁₃₆N₂₂O₃₂S₆
SMILES

O=C(NC(CC1=C(SC2=CC=C(C=C2)[N+]([O-])=O)NC3=CC=CC=C31)C=O)CCC(CCC(NC(C=O)CC4=C(NC5=C4C=CC=C5)SC6=CC=C(C=C6)[N+]([O-])=O)=O)(NC(CNC(CCOCCOCCOCCOCCC(NCC(NC(CCC(NC(C=O)CC7=C(NC8=C7C=CC=C8)SC9=CC=C(C=C9)[N+]([O-])=O)=O)(CCC(NC(C=O)CC%10=C(NC%11=C%10C=CC=C%11)SC%12=CC=C(C=C%12)[N+]([O-])=O)=O)CCC(NC(CC%13=C(NC%14=C%13C=CC=C%14)SC%15=CC=C(C=C%15)[N+]([O-])=O)C=O)=O)=O)=O)=O)=O)CCC(NC(CC%16=C(NC%17=C%16C=CC=C%17)SC%18=CC=C(C=C%18)[N+]([O-])=O)C=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marta Gargantilla, et al. C‑2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARSCoV‑2 through Interaction with the Viral Spike (S) Protein. J Med Chem. 2023. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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