2. Anti-infection Membrane Transporter/Ion Channel
  3. Bacterial Potassium Channel Antibiotic
  4. Fudapirine

Fudapirine, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. Fudapirine exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. Fudapirine also inhibits hERG channel with the IC50 of 1.89 μM.

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Fudapirine

Fudapirine Chemical Structure

CAS No. : 1859978-72-5

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Based on 1 publication(s) in Google Scholar

Fudapirine Related Antibodies

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Description

Fudapirine, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. Fudapirine exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. Fudapirine also inhibits hERG channel with the IC50 of 1.89 μM.

Clinical Trial
Molecular Weight

537.09

Formula

C34H33ClN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C)CC[C@@](O)(C1=CC=CC2=C1C=CC=C2)[C@H](C3=CC=CC=C3)C4=C(N=CC(C5=CC=C(C=C5)Cl)=C4)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (46.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8619 mL 9.3094 mL 18.6189 mL
5 mM 0.3724 mL 1.8619 mL 3.7238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8619 mL 9.3094 mL 18.6189 mL 46.5471 mL
5 mM 0.3724 mL 1.8619 mL 3.7238 mL 9.3094 mL
10 mM 0.1862 mL 0.9309 mL 1.8619 mL 4.6547 mL
15 mM 0.1241 mL 0.6206 mL 1.2413 mL 3.1031 mL
20 mM 0.0931 mL 0.4655 mL 0.9309 mL 2.3274 mL
25 mM 0.0745 mL 0.3724 mL 0.7448 mL 1.8619 mL
30 mM 0.0621 mL 0.3103 mL 0.6206 mL 1.5516 mL
40 mM 0.0465 mL 0.2327 mL 0.4655 mL 1.1637 mL
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Fudapirine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fudapirine1859978-72-5WX-081WX081WX 081BacterialPotassium ChannelAntibioticKcsAanti-tuberculosisanti-mycobacterial activityhERGMycobacterium tuberculosisMDR-TBInhibitorinhibitorinhibit

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