1859978-72-5
Chemical Structure
Fudapirine
Synonym(s): WX-081; Sudapyridine
- CAS No.: 1859978-72-5
- Formula:C34H33ClN2O2
- Molecular Weight:537.09
IUPAC Name: 2-(4-((4-(hydroxycarbamoyl)benzyl)oxy)phenyl)-2H-indazole-7-carboxamide
InChIKey: MMUCHWPQRGEHDV-ZFEZZJPFSA-N
SMILES: CN(C)CC[C@@](O)(C1=CC=CC2=C1C=CC=C2)[C@H](C3=CC=CC=C3)C4=C(N=CC(C5=CC=C(C=C5)Cl)=C4)OC
Biological Activity: Fudapirine (WX-081; Sudapyridine) is an orally active bactericidal agent that targets mycobacterial ATP synthase. Fudapirine induces mycobacterial death by inhibiting ATP synthesis, disrupting proton motive force and depleting bacterial energy. Fudapirine can be used in the research of tuberculosis and *Mycobacterium tuberculosis* infection[1][2][3][4][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fudapirine | 95.0% | Fudapirine (WX-081; Sudapyridine) is an orally active bactericidal agent that targets mycobacterial ATP synthase. Fudapirine induces mycobacterial death by inhibiting ATP synthesis, disrupting proton motive force and depleting bacterial energy. Fudapirine can be used in the research of tuberculosis and *Mycobacterium tuberculosis* infection. | ||||||||||||||||||||
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References
- [1]. Yu C, et al. Safety, pharmacokinetics, and food effect of sudapyridine (WX-081), a novel anti-tuberculosis candidate in healthy Chinese subjects. Clinical and translational science. 2024 Feb;17(2):e13718.
- [2]. Huang Z, et al. Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent. Bioorganic & medicinal chemistry letters. 2022 Sep 01;71:128824. [Content Brief]
- [3]. Yao R, et al. Sudapyridine (WX-081), a Novel Compound against Mycobacterium tuberculosis. Microbiology spectrum. 2022 Feb 23;10(1):e0247721.
- [4]. Zhu R, et al. Activity of the Sudapyridine (WX-081) against Non-Tuberculous Mycobacteria Isolated in Beijing, China. Microbiology spectrum. 2022 Dec 21;10(6):e0137222. [Content Brief]
- [6]. Xiao H, et al. In vitro and Intracellular Antibacterial Activity of Sudapyridine (WX-081) Against Tuberculosis. Infection and drug resistance. 2023;16:217-224.
- [7]. Li X, et al. Sudapyridine (WX-081) inhibits Mycobacterium tuberculosis by targeting ATP synthase and upregulating host innate immunity. mSphere. 2025 Jun 25;10(6):e0014925.
