Anti-MRSA agent 5 

Anti-MRSA agent 5 (B14) is a potent
MRSA
agent with MIC₅₀ values of 0.38 μg/mL and has low hERG activity with an IC₅₀ values of >40 μM. Anti-MRSA agent 5 (B14) also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance^[1].

MIC: 0.38 μg/mL (MRSA); IC50: >40 Μm (hERG)

Anti-MRSA agent 5 (B14) is highly selective toxic in bacterial cells. Anti-MRSA agent has marginal inhibitory activities with an IC₅₀ values of exceeding 40 μM. Anti-MRSA agent 5 (B14) has strong antibacterial activity for all five clinical isolates of MRSA (NRS-1, NRS-70, NRS-100, NRS-108, NRS-271) with MIC values between < 0.17 and 0.69 μg/mL.Anti-MRSA agent 5 (B14) inhibits all three clinical isolates of fluoroquinolone-resistant MRSA (19-25, 19-26, 19-27) and exhibits good potency against VISA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

442.47

C₂₅H₂₂N₄O₄

2490154-44-2

O=C(C1=CN(C2CC2)C3=C(C=CC(NC4=NC=CC(OC5=CC=C(C)C(C)=C5)=N4)=C3)C1=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Runzhe Songa, et al, Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Bioorg Chem. 2020 Oct;103:104176.  [Content Brief]