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Cat. No.: HY-149013

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Anti-MRSA agent 5

Anti-MRSA agent 5 (B14) is a potent
MRSA
agent with MIC₅₀ values of 0.38 μg/mL and has low hERG activity with an IC₅₀ values of >40 μM. Anti-MRSA agent 5 (B14) also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance.

For research use only. We do not sell to patients.

CAS No.: 2490154-44-2
Formula: C₂₅H₂₂N₄O₄
Molecular Weight:442.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anti-MRSA agent 5 Chemical Structure

CAS No.: 2490154-44-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

MIC: 0.38 μg/mL (MRSA); IC50: >40 Μm (hERG)

In Vitro

Anti-MRSA agent 5 (B14) is highly selective toxic in bacterial cells. Anti-MRSA agent has marginal inhibitory activities with an IC₅₀ values of exceeding 40 μM. Anti-MRSA agent 5 (B14) has strong antibacterial activity for all five clinical isolates of MRSA (NRS-1, NRS-70, NRS-100, NRS-108, NRS-271) with MIC values between < 0.17 and 0.69 μg/mL.Anti-MRSA agent 5 (B14) inhibits all three clinical isolates of fluoroquinolone-resistant MRSA (19-25, 19-26, 19-27) and exhibits good potency against VISA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:

A549, MDA-MB-231, PC-3, ABAE.
Concentration:

0–400 μM
Incubation Time:

48h
Result:

Showed marginal inhibitory activities with anIC₅₀ exceeding 40 μM and displayed highly selective toxicity toward bacterial cells.

Chemical Information

CAS No. 2490154-44-2
Molecular Weight 442.47
Formula C₂₅H₂₂N₄O₄
SMILES

O=C(C1=CN(C2CC2)C3=C(C=CC(NC4=NC=CC(OC5=CC=C(C)C(C)=C5)=N4)=C3)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Runzhe Songa, et al, Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Bioorg Chem. 2020 Oct;103:104176. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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