PqsR-IN-1
PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 2982271-62-3
- Formula: C17H18ClN3OS
- Molecular Weight:347.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PqsR[1]
PqsR-IN-1 (Compound 18) inhibits pqs system with IC50 values of 313 ± 156.2 nM and 342 ± 39.4 nM against two different PA strains PAO1-L and PA14, respectively[1].
PqsR-IN-1 significantly reduces pyocyanin production to 23% against a control of 0.1% DMSO at 3 × the IC50 value in P. aeruginosa strain PAO1-L[1].
PqsR-IN-1 (0-100 μM, 16 h) shows no significant toxicity to A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 lung epithelial cells
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Concentration:0.1, 1, 12.5, 25, 50, and 100 µM
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Incubation Time:16 h
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Result:Showed no significant toxicity.
Chemical Information
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CAS No. 2982271-62-3
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Molecular Weight 347.86
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Formula C17H18ClN3OS
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SMILES
CCCCCC1=NC(CN2C=NC3=CC=C(C=C3C2=O)Cl)=CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PqsR-IN-1 Related Classifications
HY-146705 Related Classifications
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