1. Anti-infection
  2. Bacterial
  3. PqsR-IN-1

PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity.

For research use only. We do not sell to patients.

PqsR-IN-1 Chemical Structure

PqsR-IN-1 Chemical Structure

CAS No. : 1333636-58-0

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Description

PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity[1].

IC50 & Target

PqsR[1]

In Vitro

PqsR-IN-1 (Compound 18) inhibits pqs system with IC50 values of 313 ± 156.2 nM and 342 ± 39.4 nM against two different PA strains PAO1-L and PA14, respectively[1].
PqsR-IN-1 significantly reduces pyocyanin production to 23% against a control of 0.1% DMSO at 3 × the IC50 value in P. aeruginosa strain PAO1-L[1].
PqsR-IN-1 (0-100 µM, 16 h) shows no significant toxicity to A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A549 lung epithelial cells
Concentration: 0.1, 1, 12.5, 25, 50, and 100 µM
Incubation Time: 16 h
Result: Showed no significant toxicity.
Molecular Weight

347.86

Formula

C17H18ClN3OS

CAS No.
SMILES

CCCCCC1=NC(CN2C=NC3=CC=C(C=C3C2=O)Cl)=CS1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PqsR-IN-1 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PqsR-IN-1
Cat. No.:
HY-146705
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