Anti-MRSA agent 10
Anti-MRSA agent 10 (Compound 2d) is a Cephalosporin (HY-144229) derivative and exhibits antibacterial activity. Anti-MRSA agent 10 is slightly drug resistane and exhibits low cytotoxicity in cells HUVEC and HBZY-1.
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- Formel: C30H36F3N7O8S2
- Molecular Weight:743.77
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HBZY-1 | CC50 |
>128 μg/mL
Compound: 2d
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Cytotoxicity against rat HBZY-1 cells assessed as reduction in cell viability by CCK-8 assay
Cytotoxicity against rat HBZY-1 cells assessed as reduction in cell viability by CCK-8 assay
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[PMID: 38447461] |
| HUVEC | CC50 |
>128 μg/mL
Compound: 2d
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Cytotoxicity against HUVEC assessed as reduction in cell viability by CCK-8 assay
Cytotoxicity against HUVEC assessed as reduction in cell viability by CCK-8 assay
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[PMID: 38447461] |
In Vitro
Anti-MRSA agent 10 reveals no significant cytotoxicity in sheep red blood cells, HUVECs and HBZY-1 cells, with a safe dose of more than 128 μg/mL[1].
Anti-MRSA agent 10 is antibacterial active against Gram-negative Stenotrophomonas maltophilia and Staphylococcus aureus, Gram-positiveEscherichia coli and Stenotrophomonas maltophilia, and methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 0.7, 4, 8, 8 and 2-4 μg/mL, respectively[1].
Anti-MRSA agent 10 (0-128 μg/mL) inhibits cellular respiration and viability in bacteria S. aureus through targeting penicilin binding proteins (PBP), disrupting bacterial cell wall structure and promoting oxidative damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. Aureus, HUEVC, HBZY-1
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Concentration:0-128 μg/mL
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Incubation Time:48 h
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Result:Inhibited metabolic process of S. aureus.
Maintained viability of HUVEC and HBZY-1 cells.
Chemical Information
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Molecular Weight 743.77
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Formel C30H36F3N7O8S2
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SMILES
O=C1[C@@H](NC(/C(C2=CSC([NH3+])=N2)=N\OC)=O)[C@H]3SCC(C[N+]4=CC(C(NCCCCCCCC)=O)=CC=C4)=C(C([O-])=O)N31.[O-]C(C(F)(F)F)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Anti-MRSA agent 10 Related Classifications
HY-161330 Related Classifications
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