DprE1-IN-1
DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent activity against both agent-susceptible and clinically isolated drug-resistant Tuberculosis strains with MICs10 CFU reduction in macrophages.
For research use only. We do not sell to patients.
- CAS No.: 920459-41-2
- Formula: C19H21N3O6S2
- Molecular Weight:451.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MICs: <0.1 μg/mL (Tuberculosis strains)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
62.89 μg/mL
Compound: 17b
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Cytotoxicity against human HepG2 cells measured by MTT assay
Cytotoxicity against human HepG2 cells measured by MTT assay
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[PMID: 35101648] |
| J774.A1 | IC50 |
>64 μg/mL
Compound: 17b
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Cytotoxicity against mouse J774.A1 cells measured by MTT assay
Cytotoxicity against mouse J774.A1 cells measured by MTT assay
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[PMID: 35101648] |
| Vero | IC50 |
58.18 μg/mL
Compound: 17b
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Cytotoxicity against African green monkey Vero cells measured by MTT assay
Cytotoxicity against African green monkey Vero cells measured by MTT assay
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[PMID: 35101648] |
DprE1-IN-1 (compound 17b) (64 to 0.26 μg/mL; 48 hours) has high safety with low cytotoxicity towards HepG2, J774A.1 macrophage cells (IC50>60 μg/mL) and Vero (IC50=58.18 μg/mL) alongside potent efficacy and good druggability[1].
DprE1-IN-1 can reduce 1.19 and 1.29 log10 CFU M. tuberculosis in J774A.1 macrophages at 5 μg/mL and 10 μg/mL, respectively, for 3 days treatment[1].
DprE1-IN-1 (compound 17b) (1 μM; 0-120 minutes) has high stability in human and mice hepatocytes (remaining of 42% and 49.7%, respectively; t1/2 of 24.0 and 29.7 min, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero, HepG2 and mouse J774A.1 macrophage cells[1]
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Concentration:64 to 0.26 μg/mL
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Incubation Time:48 hours
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Result:Displayed high safety with low cytotoxicity towards HepG2, J774A.1 macrophage cells (IC50>60 μg/mL) and Vero (IC50=58.18 μg/mL) alongside potent efficacy and good druggability.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female SPF Balb/c mice (18-20 g) (M. tuberculosis H37Rv infected)[1]
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Dosage:100 mg/kg
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Administration:Oral gavage; 5 days per week from day 10 until day 30
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Result:Reduced the bacterial burden in the lungs by 0.54 log10 CFU compared with the untreated control group after three weeks of treatment.
Chemical Information
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CAS No. 920459-41-2
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Molecular Weight 451.52
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Formula C19H21N3O6S2
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SMILES
O=C(OCC)NC(C1=C(NC(C2=CC=C(S(=O)(N3CCCC3)=O)C=C2)=O)SC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DprE1-IN-1 Related Classifications
HY-144341 Related Classifications
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