920459-41-2
Chemical Structure
DprE1-IN-1
- CAS No.: 920459-41-2
- Formula:C19H21N3O6S2
- Molecular Weight:451.52
IUPAC Name: ethyl (2-(4-(pyrrolidin-1-ylsulfonyl)benzamido)thiophene-3-carbonyl)carbamate
InChIKey: FFUVSZKOCCMGPX-UHFFFAOYSA-N
SMILES: O=C(OCC)NC(C1=C(NC(C2=CC=C(S(=O)(N3CCCC3)=O)C=C2)=O)SC=C1)=O
Biological Activity: DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent activity against both agent-susceptible and clinically isolated drug-resistant Tuberculosis strains with MICs10 CFU reduction in macrophages.
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DprE1-IN-1 | DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent activity against both agent-susceptible and clinically isolated drug-resistant Tuberculosis strains with MICs10 CFU reduction in macrophages. | |||||||||||||||||||||
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Keywords
