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Cat. No.: HY-147884

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Antitubercular agent-28

Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC₅₀ value of 1.5 µM, an MIC value of 4.5 µM, an IC₉₀ value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity.

For research use only. We do not sell to patients.

CAS No.: 2460651-10-7
Formula: C₁₇H₁₄N₄O₂
Molecular Weight:306.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antitubercular agent-28 Chemical Structure

CAS No.: 2460651-10-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Antitubercular agent-28 (compound 2) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC₅₀s of 2.9, 125, 130, 1.3, 3.8 µM, MICs of 3.3, 170, 190, 1.8, 8.4 µM, IC₉₀s of 3.1, 140, 180, 1.5, 4.8 µM for FQ-R1, INH-R1, INH-R2, RIF-R1,RIF-R2 respectively^[1].
Antitubercular agent-28 (0-200 µM) shows antibacterial activity with an MIC value of 170 µM, IC₅₀ value of 2.96 µM, and IC₉₀ value of 19 µM in low oxygen condition, and an MIC value of 1.77 µM, IC₅₀ value of 1.02 µM, and IC₉₀ value of 1.34 µM in normal oxygen condition^[1].
Antitubercular agent-28 (0-200 µM) shows intracellular activity with an IC₅₀ value of 2.15 µM, and IC₉₀ value of 2.85 µM, and low cytotoxicity with an IC₅₀ value of >100 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2460651-10-7
Molecular Weight 306.32
Formula C₁₇H₁₄N₄O₂
SMILES

O=C(NN1C(C2CC2)=NC3=C(C=CC=C3)C1=O)C4=CC=NC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Patel H, et al. Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis. Bioorg Chem. 2020 Sep;102:104099. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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