hDHODH-IN-11
hDHODH-IN-11 is a potent human dihydroorotate dehydrogenase (hDHODH) inhibitor with an IC50 value of 7.2 nM. hDHODH-IN-11 has low cytotoxicity. hDHODH-IN-11 can be used in research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 2396653-34-0
- Formula: C24H23N3O3
- Molecular Weight:401.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 7.2 nM (hDHODH)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | EC50 |
110 nM
Compound: 4
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Induction of apoptosis in human THP-1 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
Induction of apoptosis in human THP-1 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
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[PMID: 36162075] |
| THP-1 | EC50 |
74 nM
Compound: 4
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Induction of cell differentiation in human THP-1 cells measured for 2 days by flow cytometric analysis
Induction of cell differentiation in human THP-1 cells measured for 2 days by flow cytometric analysis
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[PMID: 36162075] |
| U-937 | EC50 |
452 nM
Compound: 4
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Induction of apoptosis in human U-937 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
Induction of apoptosis in human U-937 cells measured after 3 days by Annexin-V-FITC staining based FACS analysis
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[PMID: 36162075] |
| U-937 | EC50 |
61 nM
Compound: 4
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Induction of cell differentiation in human U-937 cells measured for 2 days by flow cytometric analysis
Induction of cell differentiation in human U-937 cells measured for 2 days by flow cytometric analysis
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[PMID: 36162075] |
hDHODH-IN-11 (0.1 and 1 μM; 72 h; THP1 and U937 cells) has low cytotoxicity, pro-apoptotic and pro-differentiating abilities[1].
hDHODH-IN-11 (0.1 μM; 72 h; THP1 and MV4-11 cells) with Dipyridamole (HY-B0312) results in synergistic effect and demonstrates a good pro-apoptotic activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice with AML xenografts[1]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection; daily, for 13 days
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Result:Reduced the leukemic burden and tumor weight.
Chemical Information
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CAS No. 2396653-34-0
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Molecular Weight 401.46
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Formula C24H23N3O3
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SMILES
O=C(C1=C2C=CC=CN2N=C1O)NC3=CC(C)=C(OC4=CC=CC=C4)C=C3C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hDHODH-IN-11 Related Classifications
HY-151560 Related Classifications
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