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Cat. No.: HY-183157

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HIV-1-IN-93

HIV-1-IN-93 is a HIV-1 RNase H inhibitor with an IC₅₀ of 6.09 μM. HIV-1-IN-93 shows low cytotoxicity and can be used in studies related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 2366269-07-8
Formula: C₁₆H₁₀F₃N₃O₄
Molecular Weight:365.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HIV-1-IN-93 Chemical Structure

CAS No.: 2366269-07-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

HIV-1-IN-93 is a HIV-1 RNase H inhibitor with an IC₅₀ of 6.09 μM. HIV-1-IN-93 shows low cytotoxicity and can be used in studies related to HIV-1 infection^[1].

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	315.9 μM Compound: I-4	Cytotoxicity in mock-infected human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay Cytotoxicity in mock-infected human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay	[PMID: 31324562]

In Vitro

HIV-1-IN-93 (compound I-4) (5 days) exhibits no significant anti-HIV-1 (IIIB) or anti-HIV-2 (ROD) activity in MT-4 cells, and shows low cytotoxicity in these cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MT-4 cells infected with wild-type HIV-1 (IIIB) or HIV-2 (ROD)
Concentration:

/
Incubation Time:

5 days
Result:

Did not exhibit significant anti-HIV activity against HIV-1 (IIIB) or HIV-2 (ROD) at the highest concentration tested, with EC₅₀ values >315.9 µM for both strains.
Showed low cytotoxicity, with a CC₅₀ value of 315.9 µM in MT-4 cells.

Chemical Information

CAS No. 2366269-07-8
Molecular Weight 365.27
Formula C₁₆H₁₀F₃N₃O₄
SMILES

O=C(NC1=CC=C2C(=O)N(O)C(=O)NC2=C1)C3=CC=C(C=C3)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gao P, et al. Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase. Bioorg Med Chem. 2019 Sep 1;27(17):3836-3845. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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HIV-1-IN-93

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HIV-1-IN-93 Related Classifications

HY-183157 Related Classifications