country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-136783

Copy Link Print Information

G6PD-IN-2

G6PD-IN-2 is a Plasmodium falciparum glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀ value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (PfGluPho) with an IC₅₀ value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria.

For research use only. We do not sell to patients.

CAS No.: 333311-00-5
Formula: C₁₈H₁₇NO₃S
Molecular Weight:327.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

G6PD-IN-2 Chemical Structure

CAS No.: 333311-00-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Parasite Isoforms :

In Vitro

G6PD-IN-2 (Compound CB83) shows time-dependent inhibition of recombinant human G6PD with an IC₅₀ of 0.2 μM after 1 h preincubation/1 h postincubation, but only weak, time-independent inhibition of recombinant Plasmodium falciparum PfGluPho, with an IC₅₀ of 22.0 μM under the same preincubation/postincubation conditions^[1].
G6PD-IN-2 (72 h) inhibits in vitro growth of Plasmodium falciparum 3D7 parasites with an IC₅₀ of 5.3 μM^[1].
G6PD-IN-2 (0.01-50 μM; 24 h) exhibits low cytotoxicity against Fa2N-4 human immortalized hepatocytes, with an LC₅₀ of 81.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Fa2N-4 human immortalized hepatocytes
Concentration:

0.01-50 μM
Incubation Time:

24 h
Result:

Showed a cytotoxicity LC₅₀ of 81.3 μM.

Chemical Information

CAS No. 333311-00-5
Molecular Weight 327.40
Formula C₁₈H₁₇NO₃S
SMILES

O=S(=O)(NC1=CC=C(O)C=2C=CC=CC12)C3=CC(=CC=C3C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Preuss J, et al. High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase. J Biomol Screen. 2012;17(6):738-751. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock