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Cat. No.: HY-147820

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AY1511

AY1511 is an amyloid β (Aβ) aggregation inhibitor with low cytotoxicity.

For research use only. We do not sell to patients.

CAS No.: 2559709-99-6
Formula: C₁₇H₁₄O₆
Molecular Weight:314.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AY1511 Chemical Structure

CAS No.: 2559709-99-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AY1511 is an amyloid β (Aβ) aggregation inhibitor with low cytotoxicity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
PC-12	CC₅₀	114 μM Compound: AY1511	Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay	[PMID: 33611188]
PC-12	CC₅₀	114 μM Compound: 2; AY1511	Cytotoxicity against rat PC12 cells measured for 24 hrs by WST-assay Cytotoxicity against rat PC12 cells measured for 24 hrs by WST-assay	[PMID: 38740144]

Chemical Information

CAS No. 2559709-99-6
Molecular Weight 314.29
Formula C₁₇H₁₄O₆
SMILES

O=C1CC(C2=CC(O)=CC=C2O)OC(C3=CC=C(O)C(O)=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hotsumi M, et al. Design, synthesis and evaluation of diaryl γ-dihydropyrone derivatives as cyclocurcumin mimetics and inhibitors of the aggregation of amyloid β. Bioorg Chem. 2020 Nov;104:104302. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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