1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    Cytoskeleton
    TGF-beta/Smad
  2. ROCK
  3. HSD1590

HSD1590 

Cat. No.: HY-126275
Handling Instructions

HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity.

For research use only. We do not sell to patients.

HSD1590 Chemical Structure

HSD1590 Chemical Structure

CAS No. : 2379279-96-4

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity[1].

IC50 & Target[1]

ROCK1

1.22 nM (IC50)

ROCK2

0.51 nM (IC50)

In Vitro

HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration[1].
HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration[1].

Cell Viability Assay[1]

Cell Line: MDA-MB-23 cells
Concentration: 0.5-10 µM
Incubation Time: 12-24 hours
Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h.
Molecular Weight

359.19

Formula

C₂₀H₁₈BN₃O₃

CAS No.

2379279-96-4

SMILES

COC(C(B(O)O)=CC=C1)=C1C(C2=C3CCC2)=NC4=C3C(C=NN5)=C5C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (278.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7840 mL 13.9202 mL 27.8404 mL
5 mM 0.5568 mL 2.7840 mL 5.5681 mL
10 mM 0.2784 mL 1.3920 mL 2.7840 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (17.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (17.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (17.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

HSD1590HSD 1590HSD-1590ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKlowcytotoxicitymigrationviabilityMDA-MB-231cellsInhibitorinhibitorinhibit

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HSD1590
Cat. No.:
HY-126275
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