UAWJ246
UAWJ246 is a covalent reversible inhibitor of the SARS-CoV-2 main protease (Mpro), with an IC50 of 0.045 μM and a Ki of 0.036 μM. UAWJ246 exhibits potent antiviral activity by inhibiting SARS-CoV-2 viral replication and shows low cytotoxicity. UAWJ246 can be used in research related to SARS-CoV-2 infection, such as studies on COVID-19[1][2].
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- CAS No.: 1429218-79-0
- Formule: C25H34N4O6
- Masse moléculaire:486.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
SARS-CoV-2 main protease 0.045 μM (IC50) |
SARS-CoV-2 main protease 0.036 μM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Vero C1008 | EC50 |
4.61 μM
Compound: 60; UAWJ246
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Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay
Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay
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[PMID: 37244162] |
In Vitro
UAWJ246 (0.37-30 μM, 48 h) inhibits SARS-CoV-2 viral replication in Vero E6 cells in a dose-dependent manner[1].
UAWJ246 (3 days) inhibits the viral replication of SARS-CoV-2 in Vero E6 cells with an EC50 of 4.61 μM in the plaque assay[1].
UAWJ246 (5 days) shows low cytotoxicity in multiple cell lines with CC50s > 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero E6 cells
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Concentration:0.37, 1.1, 3.3, 10, 30 μM
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Incubation Time:48 h
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Result:Inhibited the viral replication in a dose-response manner.
Showed an EC50 of 15.13 μM.
Chemical Information
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CAS No. 1429218-79-0
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Masse moléculaire 486.57
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Formule C25H34N4O6
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SMILES
[C@@H](C[C@H]1C(=O)NCC1)(NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(C)C)=O)C(C(NC3CC3)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sacco MD, et al. Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L. Sci Adv. 2020;6(50):eabe0751. Published 2020 Dec 9. [Content Brief]
[2]. La Monica G, et al. Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure-Activity Relationship Insights and Evolution Perspectives. J Med Chem. 2022;65(19):12500-12534. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UAWJ246 Related Classifications
HY-180387 Related Classifications
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