Neuraminidase-IN-13
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells. Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- CAS No.: 2222067-23-2
- Formula: C13H13F7N4O7
- Molecular Weight:470.25
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Neuraminidase-IN-13 inhibits plaque formation in NDV La Sota strain with an IC50 value of 0.06 μM[1].
Neuraminidase-IN-13 inhibits viral proliferation with an IC50 of 0.04 μM[1].
Neuraminidase-IN-13 has no cytotoxicity to cells, with the CC50 value is greater than 2500 μM[1].
Neuraminidase-IN-13 inhibits virus binding Vero cells with an IC50 of 4 μM[1].
Neuraminidase-IN-13 inhibits virus release with an IC50 value of 0.09 μM in Vero cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2222067-23-2
-
Molecular Weight 470.25
-
Formula C13H13F7N4O7
-
SMILES
FC(F)(F)C(F)(F)C(F)(F)C(N[C@H]1[C@](OC(C(O)=O)=C[C@@H]1N=[N+]=[N-])([H])[C@H](O)[C@H](O)CO)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)