2. Anti-infection Cell Cycle/DNA Damage
  3. CHIKV Nucleoside Antimetabolite/Analog
  4. CHIKV-IN-1

CHIKV-IN-1 (Compound 3a) is a compound that inhibits the Chikungunya virus (CHIKV) with an EC50 of 0.12 μM. CHIKV-IN-1 is a potent inhibitor of the S-adenosyl-L-homocysteine hydrolase (SAH hydrolase), with an IC50 of 0.36 μM. CHIKV-IN-1 is only effective against CHIKV and some other alphaviruses, but has no activity against other RNA viruses such as SARS-CoV, MERS-CoV, and ZIKV. CHIKV-IN-1 has extremely low cytotoxicity (CC₅₀ > 250 μM), and it has an extremely high selectivity index (SI > 2083). CHIKV-IN-1 can be used in research on anti-Chikungunya virus.

For research use only. We do not sell to patients.

CHIKV-IN-1

CHIKV-IN-1 Chemical Structure

CAS No. : 2236598-97-1

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CHIKV-IN-1 Related Antibodies

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Description

CHIKV-IN-1 (Compound 3a) is a compound that inhibits the Chikungunya virus (CHIKV) with an EC50 of 0.12 μM. CHIKV-IN-1 is a potent inhibitor of the S-adenosyl-L-homocysteine hydrolase (SAH hydrolase), with an IC50 of 0.36 μM. CHIKV-IN-1 is only effective against CHIKV and some other alphaviruses, but has no activity against other RNA viruses such as SARS-CoV, MERS-CoV, and ZIKV. CHIKV-IN-1 has extremely low cytotoxicity (CC₅₀ > 250 μM), and it has an extremely high selectivity index (SI > 2083). CHIKV-IN-1 can be used in research on anti-Chikungunya virus[1].
Cellular Effect
Cell Line Type Value Description References
Vero C1008 CC50
> 250 μM
Compound: 3a
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTS assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTS assay
[PMID: 31841728]
Vero C1008 EC50
0.12 μM
Compound: 3a
Antiviral activity against CHIKV LS3 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect pretreated with compound followed by viral infection and measured at 96 hrs post-infection by MTS assay
Antiviral activity against CHIKV LS3 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect pretreated with compound followed by viral infection and measured at 96 hrs post-infection by MTS assay
[PMID: 31841728]
Molecular Weight

297.29

Formula

C12H16FN5O3
CAS No.
SMILES

F[C@H]1[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]([C@@H]([C@H]1CCO)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHIKV-IN-1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHIKV-IN-12236598-97-1CHIKVNucleoside Antimetabolite/AnalogChikungunya virus60-fluorohomoaristeromycinAnti-RNA virusChikungunyaS-adenosylhomocysteine hydrolaseElectrophilic fluorinatioInhibitorinhibitorinhibit

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