CHIKV-IN-1
CHIKV-IN-1 (Compound 3a) is a compound that inhibits the Chikungunya virus (CHIKV) with an EC50 of 0.12 μM. CHIKV-IN-1 is a potent inhibitor of the S-adenosyl-L-homocysteine hydrolase (SAH hydrolase), with an IC50 of 0.36 μM. CHIKV-IN-1 is only effective against CHIKV and some other alphaviruses, but has no activity against other RNA viruses such as SARS-CoV, MERS-CoV, and ZIKV. CHIKV-IN-1 has extremely low cytotoxicity (CC₅₀ > 250 μM), and it has an extremely high selectivity index (SI > 2083). CHIKV-IN-1 can be used in research on anti-Chikungunya virus.
For research use only. We do not sell to patients.
- CAS No.: 2236598-97-1
- Formula: C12H16FN5O3
- Molecular Weight:297.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
>250 μM
Compound: 3a
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTS assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTS assay
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[PMID: 31841728] |
| Vero C1008 | EC50 |
0.12 μM
Compound: 3a
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Antiviral activity against CHIKV LS3 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect pretreated with compound followed by viral infection and measured at 96 hrs post-infection by MTS assay
Antiviral activity against CHIKV LS3 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect pretreated with compound followed by viral infection and measured at 96 hrs post-infection by MTS assay
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[PMID: 31841728] |
Chemical Information
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CAS No. 2236598-97-1
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Molecular Weight 297.29
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Formula C12H16FN5O3
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SMILES
F[C@H]1[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]([C@@H]([C@H]1CCO)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHIKV-IN-1 Related Classifications
HY-133135 Related Classifications
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