DNA polymerase-IN-6
DNA polymerase-IN-6 is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 can be used in research related to viral infections.
For research use only. We do not sell to patients.
- CAS No.: 2701561-91-1
- Formula: C26H28ClFN8O4
- Molecular Weight:571.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
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DNA Polymerase |
DNA polymerase-IN-6 (compound 27) inhibits the replication of HCMV in MRC-5 cells with an EC50 value of 0.33 μM; additionally, it shows no cytotoxicity against MRC-5 cells at concentrations up to 40 μM[1].
DNA polymerase-IN-6 inhibits plaque formation of HCMV in HFF-1 cells, with an EC50 value of 0.21 μM[1].
DNA polymerase-IN-6 inhibits the HCMV Davis strain in MRC-5 cells with an EC50 of 0.20 μM, and shows no cytotoxicity against MRC-5 cells at concentrations up to 40 μM[1].
DNA polymerase-IN-6 inhibits the replication of HSV-1 in Vero cells with an EC50 of 1.9 μM, and shows no cytotoxicity against Vero cells at concentrations up to 40 μM[1].
DNA polymerase-IN-6 inhibits the replication of HSV-2 in Vero cells with an EC50 of 0.76 μM, and shows no cytotoxicity against Vero cells[1].
DNA polymerase-IN-6 inhibits EBV replication in B95-8 marmoset B cells, with an EC50 of 0.066 μM, a CC50 of 5.5 μM in B95-8 cells, and a selectivity index of 83[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2701561-91-1
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Molecular Weight 571.00
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Formula C26H28ClFN8O4
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SMILES
NCCN1CCN(C2=NC(C=C(C(NCC3=CC=C(Cl)C=C3)=O)C(N4CC(N5CC(C)(F)C5)=O)=O)=C4N=C2)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)