DNA polymerase-IN-6 formic
Based on 1 Customer Validation
DNA polymerase-IN-6 formic is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 formic inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 formic exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 formic can be used in research related to viral infections.
For research use only. We do not sell to patients.
- Formula: C27H30ClFN8O6
- Molecular Weight:617.03
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
DNA polymerase-IN-6 (compound 27) formic inhibits the replication of HCMV in MRC-5 cells with an EC50 value of 0.33 μM; additionally, it shows no cytotoxicity against MRC-5 cells at concentrations up to 40 μM[1].
DNA polymerase-IN-6 formic inhibits plaque formation of HCMV in HFF-1 cells, with an EC50 value of 0.21 μM[1].
DNA polymerase-IN-6 formic inhibits the HCMV Davis strain in MRC-5 cells with an EC50 of 0.20 μM, and shows no cytotoxicity against MRC-5 cells at concentrations up to 40 μM[1].
DNA polymerase-IN-6 formic inhibits the replication of HSV-1 in Vero cells with an EC50 of 1.9 μM, and shows no cytotoxicity against Vero cells at concentrations up to 40 μM[1].
DNA polymerase-IN-6 formic inhibits the replication of HSV-2 in Vero cells with an EC50 of 0.76 μM, and shows no cytotoxicity against Vero cells[1].
DNA polymerase-IN-6 formic inhibits EBV replication in B95-8 marmoset B cells, with an EC50 of 0.066 μM, a CC50 of 5.5 μM in B95-8 cells, and a selectivity index of 83[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 617.03
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Formula C27H30ClFN8O6
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SMILES
O=CO.NCCN1CCN(C2=NC(C=C(C(NCC3=CC=C(Cl)C=C3)=O)C(N4CC(N5CC(C)(F)C5)=O)=O)=C4N=C2)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (162.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6207 mL | 8.1033 mL | 16.2067 mL | 40.5167 mL |
| 5 mM | 0.3241 mL | 1.6207 mL | 3.2413 mL | 8.1033 mL | |
| 10 mM | 0.1621 mL | 0.8103 mL | 1.6207 mL | 4.0517 mL | |
| 15 mM | 0.1080 mL | 0.5402 mL | 1.0804 mL | 2.7011 mL | |
| 20 mM | 0.0810 mL | 0.4052 mL | 0.8103 mL | 2.0258 mL | |
| 25 mM | 0.0648 mL | 0.3241 mL | 0.6483 mL | 1.6207 mL | |
| 30 mM | 0.0540 mL | 0.2701 mL | 0.5402 mL | 1.3506 mL | |
| 40 mM | 0.0405 mL | 0.2026 mL | 0.4052 mL | 1.0129 mL | |
| 50 mM | 0.0324 mL | 0.1621 mL | 0.3241 mL | 0.8103 mL | |
| 60 mM | 0.0270 mL | 0.1351 mL | 0.2701 mL | 0.6753 mL | |
| 80 mM | 0.0203 mL | 0.1013 mL | 0.2026 mL | 0.5065 mL | |
| 100 mM | 0.0162 mL | 0.0810 mL | 0.1621 mL | 0.4052 mL |
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