DNA polymerase-IN-6 formic

Cat. No.: HY-170547A: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

DNA polymerase-IN-6 formic is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 formic inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 formic exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 formic can be used in research related to viral infections.

For research use only. We do not sell to patients.

DNA polymerase-IN-6 formic Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of DNA polymerase-IN-6 formic:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

DNA polymerase-IN-6 (compound 27) formic inhibits the replication of HCMV in MRC-5 cells with an EC₅₀ value of 0.33 μM; additionally, it shows no cytotoxicity against MRC-5 cells at concentrations up to 40 μM^[1].
DNA polymerase-IN-6 formic inhibits plaque formation of HCMV in HFF-1 cells, with an EC₅₀ value of 0.21 μM^[1].
DNA polymerase-IN-6 formic inhibits the HCMV Davis strain in MRC-5 cells with an EC₅₀ of 0.20 μM, and shows no cytotoxicity against MRC-5 cells at concentrations up to 40 μM^[1].
DNA polymerase-IN-6 formic inhibits the replication of HSV-1 in Vero cells with an EC₅₀ of 1.9 μM, and shows no cytotoxicity against Vero cells at concentrations up to 40 μM^[1].
DNA polymerase-IN-6 formic inhibits the replication of HSV-2 in Vero cells with an EC₅₀ of 0.76 μM, and shows no cytotoxicity against Vero cells^[1].
DNA polymerase-IN-6 formic inhibits EBV replication in B95-8 marmoset B cells, with an EC₅₀ of 0.066 μM, a CC₅₀ of 5.5 μM in B95-8 cells, and a selectivity index of 83^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

617.03

Formula

C₂₇H₃₀ClFN₈O₆

Appearance

Solid

SMILES

O=CO.NCCN1CCN(C2=NC(C=C(C(NCC3=CC=C(Cl)C=C3)=O)C(N4CC(N5CC(C)(F)C5)=O)=O)=C4N=C2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (162.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6207 mL	8.1033 mL	16.2067 mL
5 mM	0.3241 mL	1.6207 mL	3.2413 mL
10 mM	0.1621 mL	0.8103 mL	1.6207 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (275 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Bai B, et al., Discovery of Novel Pyrido[2,3-b]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition. ChemMedChem. 2024 Dec 10:e202400629. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6207 mL	8.1033 mL	16.2067 mL	40.5167 mL
	5 mM	0.3241 mL	1.6207 mL	3.2413 mL	8.1033 mL
	10 mM	0.1621 mL	0.8103 mL	1.6207 mL	4.0517 mL
	15 mM	0.1080 mL	0.5402 mL	1.0804 mL	2.7011 mL
	20 mM	0.0810 mL	0.4052 mL	0.8103 mL	2.0258 mL
	25 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL
	30 mM	0.0540 mL	0.2701 mL	0.5402 mL	1.3506 mL
	40 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0129 mL
	50 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.8103 mL
	60 mM	0.0270 mL	0.1351 mL	0.2701 mL	0.6753 mL
	80 mM	0.0203 mL	0.1013 mL	0.2026 mL	0.5065 mL
	100 mM	0.0162 mL	0.0810 mL	0.1621 mL	0.4052 mL