1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. NR160

NR160 

Cat. No.: HY-139181
Handling Instructions

NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly.

For research use only. We do not sell to patients.

NR160 Chemical Structure

NR160 Chemical Structure

CAS No. : 2484895-50-1

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Description

NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly[1][2].

IC50 & Target[1]

HDAC6

30 nM (IC50)

In Vitro

NR160 (compound 6I) (2.5 μM and 5 μM; 24 h) induces α-tubulin acetylation (ac-α-tubulin)[1].
NR160 (1-50 μM; 24 h) shows low cytotoxicity against leukemia cell lines with IC50s >20 μM[1].
NR160 (2.5 μM, 5 μM; 24 h) enhances the cytotoxicity induction of Bortezomib, Epirubicin and Daunorubicin in HL60 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HL60 cells
Concentration: 1-50 μM
Incubation Time: 24 hours
Result: Inhibited leukemia cell lines with IC50s of 49.4 μM (TALL-1), 51.8 μM (HSB-2), 42.4 μM (MOLT-4), 32.1 μM (Jurkat), 42.9 μM (HL-60), 22.5 μM (SUP-B15), and 41.6 μM (K562), respectively.
Molecular Weight

510.47

Formula

C25H21F3N6O3

CAS No.
SMILES

O=C(N(CC1=CC=C(C(NO)=O)C=C1)CC2=NN=NN2CC3=CC=CC=C3)C4=CC=CC=C4C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NR160
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HY-139181
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