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Cat. No.: HY-139181

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NR160

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NR160 is a selective HDAC6 inhibitor with an IC₅₀ value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly.

For research use only. We do not sell to patients.

Purity: 98.9%
CAS No.: 2484895-50-1
Formula: C₂₅H₂₁F₃N₆O₃
Molecular Weight:510.47

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

NR160 Chemical Structure

CAS No.: 2484895-50-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC6

30 nM (IC₅₀)

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-HSB-2	IC₅₀	22.5 μM Compound: 76; NR-160	Antiproliferative activity against human CCRF-HSB-2 cells Antiproliferative activity against human CCRF-HSB-2 cells	[PMID: 37875056]
CCRF-HSB-2	IC₅₀	51.8 μM Compound: 6l, NR-160	Cytotoxicity in human CCRF-HSB-2 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay Cytotoxicity in human CCRF-HSB-2 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay	[PMID: 32803970]
HL-60	IC₅₀	22.5 μM Compound: 76; NR-160	Antiproliferative activity against human HL-60 cells Antiproliferative activity against human HL-60 cells	[PMID: 37875056]
HL-60	IC₅₀	42.9 μM Compound: 6l, NR-160	Cytotoxicity in human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay Cytotoxicity in human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay	[PMID: 32803970]
Jurkat	IC₅₀	22.5 μM Compound: 76; NR-160	Antiproliferative activity against human Jurkat cells Antiproliferative activity against human Jurkat cells	[PMID: 37875056]
Jurkat	IC₅₀	32.1 μM Compound: 6l, NR-160	Cytotoxicity in human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay Cytotoxicity in human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay	[PMID: 32803970]
K562	IC₅₀	22.5 μM Compound: 76; NR-160	Antiproliferative activity against human K562 cells Antiproliferative activity against human K562 cells	[PMID: 37875056]
K562	IC₅₀	41.6 μM Compound: 6l, NR-160	Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay	[PMID: 32803970]
MOLT-4	IC₅₀	22.5 μM Compound: 76; NR-160	Antiproliferative activity against human MOLT-4 cells Antiproliferative activity against human MOLT-4 cells	[PMID: 37875056]
MOLT-4	IC₅₀	42.4 μM Compound: 6l, NR-160	Cytotoxicity in human MOLT-4 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay Cytotoxicity in human MOLT-4 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay	[PMID: 32803970]
SUP-B15	IC₅₀	22.5 μM Compound: 6l, NR-160	Cytotoxicity in human SUP-B15 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay Cytotoxicity in human SUP-B15 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay	[PMID: 32803970]
SUP-B15	IC₅₀	22.5 μM Compound: 76; NR-160	Antiproliferative activity against human SUP-B15 cells Antiproliferative activity against human SUP-B15 cells	[PMID: 37875056]
TALL-1	IC₅₀	22.5 μM Compound: 76; NR-160	Antiproliferative activity against human TALL-1 cells Antiproliferative activity against human TALL-1 cells	[PMID: 37875056]
TALL-1	IC₅₀	49.4 μM Compound: 6l, NR-160	Cytotoxicity in human TALL-1 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay Cytotoxicity in human TALL-1 cells assessed as reduction in cell viability incubated for 72 hrs by cell-Titer-Glo luminescent cell viability assay	[PMID: 32803970]

In Vitro

NR160 (compound 6I) (2.5 μM and 5 μM; 24 h) induces α-tubulin acetylation (ac-α-tubulin)^[1].
NR160 (1-50 μM; 24 h) shows low cytotoxicity against leukemia cell lines with IC50s >20 μM^[1].
NR160 (2.5 μM, 5 μM; 24 h) enhances the cytotoxicity induction of Bortezomib, Epirubicin and Daunorubicin in HL60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HL60 cells
Concentration:

1-50 μM
Incubation Time:

24 hours
Result:

Inhibited leukemia cell lines with IC50s of 49.4 μM (TALL-1), 51.8 μM (HSB-2), 42.4 μM (MOLT-4), 32.1 μM (Jurkat), 42.9 μM (HL-60), 22.5 μM (SUP-B15), and 41.6 μM (K562), respectively.

Chemical Information

CAS No. 2484895-50-1
Appearance Solid
Molecular Weight 510.47
Formula C₂₅H₂₁F₃N₆O₃
Color White to off-white
SMILES

O=C(N(CC1=CC=C(C(NO)=O)C=C1)CC2=NN=NN2CC3=CC=CC=C3)C4=CC=CC=C4C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Reßing N, et al. Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J Med Chem. 2020 Sep 24;63(18):10339-10351. [Content Brief]

[2]. Najib N N, et al. Correlation between the acoustic and dynamic mechanical properties of natural rubber foam: Effect of foaming temperature[J]. Materials & Design, 2011, 32(2): 505-511.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NR160

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NR160

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NR160 Related Classifications

Cat. No.: HY-139181