2484895-50-1
Chemical Structure
NR160
- CAS No.: 2484895-50-1
- Formula:C25H21F3N6O3
- Molecular Weight:510.47
IUPAC Name: N-((1-benzyl-1H-tetrazol-5-yl)methyl)-N-(4-(hydroxycarbamoyl)benzyl)-2-(trifluoromethyl)benzamide
InChIKey: MEWDNULKAXEKII-UHFFFAOYSA-N
SMILES: O=C(N(CC1=CC=C(C(NO)=O)C=C1)CC2=NN=NN2CC3=CC=CC=C3)C4=CC=CC=C4C(F)(F)F
Biological Activity: NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NR160 | 98.9% | NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly. | ||||||||||||||||||||
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- [1]. Reßing N, et al. Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J Med Chem. 2020 Sep 24;63(18):10339-10351. [Content Brief]
- [2]. Najib N N, et al. Correlation between the acoustic and dynamic mechanical properties of natural rubber foam: Effect of foaming temperature[J]. Materials & Design, 2011, 32(2): 505-511.
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