1. Anti-infection
    Membrane Transporter/Ion Channel
  2. Bacterial
    ATP Synthase
  3. Mtb ATP synthase-IN-1

Mtb ATP synthase-IN-1 

Cat. No.: HY-146388
Handling Instructions

Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium.

For research use only. We do not sell to patients.

Mtb ATP synthase-IN-1 Chemical Structure

Mtb ATP synthase-IN-1 Chemical Structure

CAS No. : 2642394-38-3

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Description

Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium[1].

IC50 & Target

MIC: 0.452-0.499 μg/mL (Mtb)[1]

In Vivo

Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability[1].
Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse[1].

PO (50 mg/kg) IV (5 mg/kg)
Cmax (ng/mL) 1333 1241
Tmax (h) 0.83
T1/2 (h) 0.51 0.33
AUC0-t (ng/mL·h) 2197 1667
AUC0-∞ (ng/mL·h) 2198 1672
MRT0-∞ (ng/mL) 1.36 0.28
CL (mL/min/kg) 51.4
F (%) 13.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mouse[1]
Dosage: 50 and 5 mg/kg
Administration: 50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis)
Result: Exhibited good metabolic stability and acceptable oral bioavailability.
Molecular Weight

323.30

Formula

C17H13N3O4

CAS No.
SMILES

O=C1C(C(NC2=CC=C3OCOC3=C2)=C1NCC4=NC=CC=C4)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Mtb ATP synthase-IN-1
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HY-146388
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