Mt KARI-IN-2
Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL).
For research use only. We do not sell to patients.
- CAS No.: 2413974-52-2
- Formula: C14H11N5O4S2
- Molecular Weight:377.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 2.02 μM (Mtb KARI)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
86 μM
Compound: 5b
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 32171154] |
Chemical Information
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CAS No. 2413974-52-2
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Molecular Weight 377.40
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Formula C14H11N5O4S2
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SMILES
COC1=CC=C(C=C1)NC(NC2=NN=C(S2)C3=CC=C(O3)[N+]([O-])=O)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mt KARI-IN-2 Related Classifications
HY-146299 Related Classifications
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