2413974-52-2
2413974-52-2
Chemical Structure
Mt KARI-IN-2
- CAS No.: 2413974-52-2
- Formula:C14H11N5O4S2
- Molecular Weight:377.40
IUPAC Name: 1-(4-methoxyphenyl)-3-(5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl)thiourea
InChIKey: YEELHMPVDFYKPL-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)NC(NC2=NN=C(S2)C3=CC=C(O3)[N+]([O-])=O)=S
Biological Activity: Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL)[1].
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Mt KARI-IN-2 | Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL). | |||||||||||||||||||||
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References
Keywords
