Pheanthine
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC50 is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC50 of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC50 is 11.2 μM) and macrophages (PMM, IC50 is 8 μM).
For research use only. We do not sell to patients.
- CAS No.: 1263-79-2
- Formula: C38H42N2O6
- Molecular Weight:622.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| KB | ED50 |
10800 nM
Compound: 17
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Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
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[PMID: 9917283] |
| U-937 | IC50 |
50 μM
Compound: 13, NSC 105130
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Cytotoxicity against human U937 cells after 24 hrs by alamar blue assay
Cytotoxicity against human U937 cells after 24 hrs by alamar blue assay
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[PMID: 22766217] |
Chemical Information
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CAS No. 1263-79-2
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Molecular Weight 622.75
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Formula C38H42N2O6
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SMILES
COC1=C(OC(C=C2C(CC3)=C4)=C4OC)C([C@@](N5C)([H])CC(C=C6OC(C=C7)=CC=C7C[C@@]2([H])N3C)=CC=C6OC)=C(CC5)C=C1OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)