URAT1 inhibitor 10
URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for OAT1 .
For research use only. We do not sell to patients.
- CAS No.: 3012586-38-5
- Formula: C19H20F3N3O3S
- Molecular Weight:427.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>64 μg/mL
Compound: 23a
|
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
|
[PMID: 38547733] |
| Vero | IC50 |
>64 μg/mL
Compound: 23a
|
Cytotoxicity against african green monkey Vero cells measured after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells measured after 48 hrs by MTT assay
|
[PMID: 38547733] |
URAT1 inhibitor 10 shows low cytotoxicity (IC50 > 64 μg/mL) in HepG2 cells[1].
URAT1 inhibitor 10 (5 μM; 30 min) inhibits OAT1 activity in MDCK-hOAT cells (IC50=9.17 μM)[1].
URAT1 inhibitor 10 (24 h) shows moderate inhibition of IL-6 (IR = 25.6%) in RAW264.7 cells, which may alleviate symptoms associated with MSU crystal-mediated inflammatory cytokines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
URAT1 inhibitor 10 (50 mg/kg; p.o.) has a favorable pharmacokinetic profile[1].
Pharmacokinetic Analysis in URAT1 inhibitor 10 Model[1]
| Route | Dose (mg/kg) | t1/2 (h) | tmax (h) | Cmax (ng/mL) | AUC(0-t) (ng·h/mL) | AUC(0-∞) (ng·h/mL) | MRT(0-∞) (h) |
| p.o. | 50 | 1.9 | 0.25 | 8187 | 10050 | 10255 | 1.43 |