2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2 3CLpro-IN-35

SARS-CoV-2 3CLpro-IN-35 is a SARS-CoV-2 3CLpro inhibitor with an IC50 of 0.15 μM. SARS-CoV-2 3CLpro-IN-35 inhibits the proliferation of bladder cancer cells, exerts anti-SARS-CoV-2 activity, and exhibits low cytotoxicity in fibroblasts. SARS-CoV-2 3CLpro-IN-35 is applicable to research related to SARS-CoV-2 infection and bladder cancer.

For research use only. We do not sell to patients.

SARS-CoV-2 3CLpro-IN-35

SARS-CoV-2 3CLpro-IN-35 Chemical Structure

CAS No. : 3023042-32-9

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SARS-CoV-2 3CLpro-IN-35 Related Antibodies

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Description

SARS-CoV-2 3CLpro-IN-35 is a SARS-CoV-2 3CLpro inhibitor with an IC50 of 0.15 μM. SARS-CoV-2 3CLpro-IN-35 inhibits the proliferation of bladder cancer cells, exerts anti-SARS-CoV-2 activity, and exhibits low cytotoxicity in fibroblasts. SARS-CoV-2 3CLpro-IN-35 is applicable to research related to SARS-CoV-2 infection and bladder cancer[1].

In Vitro

SARS-CoV-2 3CLpro-IN-35 (Compound L3) (25 h) potently inhibits the infection of GFP-SARS-CoV-2-S-Psv in HK-2 cells, with an EC50 of 2.82 μM[1].
SARS-CoV-2 3CLpro-IN-35 (2-40 μM; 24 h) potently inhibits the proliferation of T24 bladder cancer cells in a concentration-dependent manner, with an IC50 of 10.99 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 3CLpro-IN-35 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: T24 human bladder cancer cells
Concentration: 2, 5, 10, 20 and 40 μM
Incubation Time: 24 h
Result: Potently suppressed T24 bladder cancer cell proliferation in a concentration-dependent manner, with an IC50 of 10.99 μM after 24 h of incubation.
Molecular Weight

618.52

Formula

C32H24F6O6
CAS No.
SMILES

O=C(CCC1=CC(C2=CC=C(C=C2)C(F)(F)F)=C(C(C3=C(C(C4=CC=C(C=C4)C(F)(F)F)=CC(CCC(O)=O)=C3)O)=C1)O)O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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SARS-CoV-2 3CLpro-IN-35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 3CLpro-IN-353023042-32-9SARS-CoVSARS coronavirusSARS-CoV-2 3CLprobladder cancer cellsSARS-CoV-2 infectionT24 bladder cancer cellsfibroblastsbladder cancerS1 pocketHK-2 cellsS4 pocketInhibitorinhibitorinhibit

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