SARS-CoV-2 Mpro-IN-46
SARS-CoV-2 Mpro-IN-46 (Compound 12) is a SARS-CoV-2 main protease inhibitor with an IC50 of ∼25 μM. SARS-CoV-2 Mpro-IN-46 has potent antiviral activity with low cytotoxicity against SARS-CoV-2 (IC50: 7.4 μM). SARS-CoV-2 Mpro-IN-46 can be used for coronaviruses COVID-19 research.
For research use only. We do not sell to patients.
- CAS No.: 1800004-01-6
- Formula: C26H24ClN3
- Molecular Weight:413.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
4.38 μM
Compound: 47a
|
Cytotoxicity against human A549 cells treated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells treated for 72 hrs by MTT assay
|
[PMID: 35344904] |
| HeLa | IC50 |
<1 μM
Compound: 47a
|
Cytotoxicity against human HeLa cells treated for 72 hrs by MTT assay
Cytotoxicity against human HeLa cells treated for 72 hrs by MTT assay
|
[PMID: 35344904] |
| MCF7 | IC50 |
7.99 μM
Compound: 47a
|
Cytotoxicity against human MCF7 cells treated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells treated for 72 hrs by MTT assay
|
[PMID: 35344904] |
| PC-3 | IC50 |
43.97 μM
Compound: 47a
|
Cytotoxicity against human PC-3 cells treated for 72 hrs by MTT assay
Cytotoxicity against human PC-3 cells treated for 72 hrs by MTT assay
|
[PMID: 35344904] |
| SK-BR-3 | IC50 |
0.009 μM
Compound: 47a
|
Cytotoxicity against human SK-BR-3 cells treated for 72 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells treated for 72 hrs by MTT assay
|
[PMID: 35344904] |
Chemical Information
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CAS No. 1800004-01-6
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Molecular Weight 413.94
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Formula C26H24ClN3
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SMILES
ClC1=CC2=C(C(NC3=CC=C(C(C4=CC=CC=C4)=C3)CN5CCCC5)=CC=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)