Antileishmanial agent-36
Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research.
For research use only. We do not sell to patients.
- CAS No.: 3086122-36-0
- Formula: C24H27N5O2
- Molecular Weight:417.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Chemical Information
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CAS No. 3086122-36-0
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Molecular Weight 417.50
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Formula C24H27N5O2
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SMILES
O=C1NC(C)=C(C(C2=CC=C(N(C)C)C=C2)N1)C(NCCC3=CNC4=C3C=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-36 Related Classifications
HY-178456 Related Classifications
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