3086122-36-0
Chemical Structure
Antileishmanial agent-36
- CAS No.: 3086122-36-0
- Formula:C24H27N5O2
- Molecular Weight:417.50
InChIKey: REWHOXVRONGVRV-UHFFFAOYSA-N
SMILES: O=C1NC(C)=C(C(C2=CC=C(N(C)C)C=C2)N1)C(NCCC3=CNC4=C3C=CC=C4)=O
Biological Activity: Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research[1].
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Antileishmanial agent-36 | Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research. | |||||||||||||||||||||
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Keywords
