1. Anti-infection
  2. Virus Protease Flavivirus
  3. ZIKV-IN-1

ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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ZIKV-IN-1 Chemical Structure

ZIKV-IN-1 Chemical Structure

CAS No. : 2762166-06-1

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Description

ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain[1]. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

EC50: 2.8 µM (ZIKV)[1]

In Vitro

ZIKV-IN-1 (compound 38) (0-80 µM) shows anti-ZIKV activity in a dose-dependent manner in A549 cells[1].
ZIKV-IN-1 (5, 10, 25 µM; 48 h) decreases the expression of ZIKV E and cleaved caspase 3 protein[1].
ZIKV-IN-1 (1.25, 2.5, 5, 10, 20 µM; 0-250 s) shows strong affinity to ZIKV RdRp domain (Kd=1.87 µM) in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 0-50 µM
Incubation Time:
Result: Showed anti-ZIKV activity with an EC50 of 2.8 µM, EC90 of 6.8 µM, and CC50 of >50 µM.

Western Blot Analysis[1]

Cell Line: A549, Vero cells
Concentration: 5, 10, 25 µM
Incubation Time: 48 h
Result: Decreased the expression of ZIKV E and cleaved caspase 3 protein.

Cell Cytotoxicity Assay[1]

Cell Line: Vero, SNB19, Huh7, A549 cells
Concentration: 0-80 µM
Incubation Time:
Result: Showed low cytotoxicity with CC50s of 46.8, 49.4, 43.8, 54.1 µM for ZG01 strain of Vero, SNB19, Huh7, A549 cells, and CC50s of 470.5, 485.2, 512.8, 160.8 µM for MR766 strain of Vero, SNB19, Huh7, A549 cells, respectively.
Molecular Weight

478.29

Formula

C21H18BrF2N3O3

CAS No.
SMILES

CC1=NC=NC2=C1C(C#CC3=CC(F)=C(C=C3)Br)=CN2[C@@H]4O[C@@H]([C@H]([C@]4(F)C)O)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ZIKV-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ZIKV-IN-1
Cat. No.:
HY-146957
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