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Anti-infection
Antibiotic Arenavirus Bacterial
Beta-lactamase CHIKV CMV
Dengue Virus EBV Endoplasmic Reticulum Oxidoreductase 1 (ERO1)
Enterovirus Filovirus Flavivirus
Fungal HBV HCV
HCV Protease Hepatitis E Virus (HEV) HIV
HIV Protease HPV HSV
Influenza Virus Measles Virus Orthopoxvirus
Parasite Penicillin-binding protein (PBP) RABV
Reverse Transcriptase RSV SARS-CoV
TMV Tomato Spotted Wilt Virus (TSWV) Urease
Virus Protease VRK VSV
VZV    
Antibody-drug Conjugate/ADC Related
ADC Antibody ADC Linker ADC Payload
Antibody-Drug Conjugates (ADCs) Antibody-Oligonucleotide Conjugates (AOCs) Drug-Linker Conjugates for ADC
Peptide-Drug Conjugates (PDCs) PROTAC-Linker Conjugates for PAC Radionuclide-Drug Conjugates (RDCs)
Apoptosis
Apoptosis ASK1 Bcl-2 Family
c-Myc Caspase Cuproptosis
DAPK Ferroptosis FKBP
Glutathione Peroxidase IAP MDM-2/p53
Necroptosis PANoptosis Paraptosis
Photosensitizer PKD Pyroptosis
RIP kinase Survivin Thymidylate Synthase
TNF Receptor Transferrin Receptor  
Autophagy
Atg4 Atg7 Atg8/LC3
ATTECs AUTACs Autophagy
Beclin1 ER-phagy FKBP
LRRK2 Mitophagy p62
PINK1/Parkin ULK  
Cell Cycle/DNA Damage
Antifolate APC ATF6
ATM/ATR Aurora Kinase Casein Kinase
CDK CDKL Checkpoint Kinase (Chk)
ClpP Cyclin G-associated Kinase (GAK) Deubiquitinase
Disulfidptosis DNA Alkylator/Crosslinker DNA Stain
DNA-PK DNA/RNA Synthesis Early 2 Factor (E2F)
Endonuclease Eukaryotic Initiation Factor (eIF) FKBP
Folate Receptor (FR) G-quadruplex Haspin Kinase
HDAC HMG Family HOXA
HSP IRE1 Kinesin
LIM Kinase (LIMK) MARK MASTL
Microphthalmia Associated Transcription Factor (MITF) Microtubule/Tubulin Microtubule‐associated serine/threonine kinase (MAST)
Mitosis Mps1 NEKs
Nucleoside Antimetabolite/Analog p97 PAK
PARP PDI PERK
Polo-like Kinase (PLK) Poly(ADP-ribose) Glycohydrolase (PARG) PPAR
RAD51 ROCK Separase
Sirtuin SRPK STK33
SWI/SNF Complex Telomerase TLK
TOPK Topoisomerase Wee1
YB-1 Zinc Finger Protein  
Cytoskeleton
Annexin A Arp2/3 Complex Cadherin
Calpain Cdc42-binding kinase Cellulose Synthase
Clathrin Claudin Collagen
Connexin Dynamin Dystrophin
Exosomes Gap Junction Protein Integrin
Kinesin Lysyl Oxidase MARCKS
MASTL Microtubule/Tubulin Mps1
Myosin PAK ROCK
Tissue Factor Pathway Inhibitor (TFPI)    
Epigenetics
AMPK Aurora Kinase DNA Glycosylase
DNA Methyltransferase Epigenetic Reader Domain Glycosyltransferase
HDAC Histone Acetyltransferase Histone Demethylase
Histone Methyltransferase hnRNP HuR
JAK Methionine Adenosyltransferase (MAT) METTL3
MicroRNA PARP PKC
Protein Arginine Deiminase RNA MTase S-adenosylhomocysteine hydrolase (SAHH)
SF3B1 Sirtuin Small Interfering RNA (siRNA)
TET Protein WDR5 YTHDF
GPCR/G Protein
5-HT Receptor Adenylate Cyclase Adhesion G Protein-coupled Receptors (AGPCRs)
Adrenergic Receptor Amylin Receptor Angiotensin Receptor
Apelin Receptor (APJ) Arf Family GTPase Arrestin
Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor
CaSR CCR CGRP Receptor
Chemerin Receptor Cholecystokinin Receptor CRFR
CXCR EBI2/GPR183 Endothelin Receptor
Formyl Peptide Receptor (FPR) Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor 1
G Protein-coupled Receptor Kinase (GRK) G2A (GPR132) GHSR
GLP Receptor GnRH Receptor GPR109A
GPR119 GPR139 GPR171
GPR35 GPR39 GPR4
GPR52 GPR55 GPR6
GPR65 GPR68 GPR84
GPR88 Guanylate Cyclase Histamine Receptor
Hydroxycarboxylic Acid Receptor (HCAR) ICMT Kisspeptin Receptor
Leukotriene Receptor LPL Receptor mAChR
Mas-related G-protein-coupled Receptor (MRGPR) MCHR1 (GPR24) Melanocortin Receptor
Melanopsin Receptor Melatonin Receptor mGluR
Motilin Receptor Natriuretic Peptide Receptor (NPR) Neurokinin Receptor
Neuromedin U Receptor (NMUR) Neuropeptide B/W Receptor Neuropeptide FF Receptor
Neuropeptide S Receptor Neuropeptide Y Receptor Neurotensin Receptor
Olfactory Receptor Opioid Receptor Orexin Receptor (OX Receptor)
Orphan GPCR Orphan Receptor Oxytocin Receptor
P2Y Receptor PACAP Receptor Platelet-activating Factor Receptor (PAFR)
Prokineticin Receptor Prostaglandin Receptor Protease Activated Receptor (PAR)
PTHR Ras RGS Protein
RXFP Receptor Secretin Receptor Somatostatin Receptor
Succinate Receptor 1 Taste Receptor Trace Amine-associated Receptor (TAAR)
TSH Receptor Urotensin Receptor Vasopressin Receptor
Immunology/Inflammation
AIM2 ALCAM/CD166 AP-1
Arginase Aryl Hydrocarbon Receptor Asialoglycoprotein Receptor (ASGPR)
BCL6 C-type Lectin-like Receptors (CTLRs) CCR
CD1 CD19 CD2
CD20 CD22 CD276/B7-H3
CD28 CD3 CD38
CD44 CD47 CD6
CD73 CD74 Complement System
COX CTLA-4 CX3CR1
CXCR Cyclic GMP-AMP Synthase Cyclophilin
DOCK E-Selectin FAP
Fc Receptor (FcR) FKBP FLAP
Galectin Glucocorticoid Receptor Glycoprotein VI
Hapten Histamine Receptor Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
IFNAR IKZF Family Interleukin Related
IRAK Kallikrein L-Selectin
LAG-3 LILRB Macrophage migration inhibitory factor (MIF)
Mesothelin MHC Mucin
MyD88 Nectin-4 Ninjurin
NO Synthase NOD-like Receptor (NLR) NTPDase
Nuclear Factor of activated T Cells (NFAT) Osteopontin P-selectin
PD-1/PD-L1 PGE synthase Programmed Cell Death 4 (PDCD4)
PSMA Pyroptosis Reactive Oxygen Species (ROS)
RIG-I-like receptor (RLR) S100 Protein Salt-inducible Kinase (SIK)
Scavenger Receptor Class B type I (SR-BI) SOD SphK
STING Thrombopoietin Receptor Tim3
Toll-like Receptor (TLR) Transmembrane Glycoprotein TREM receptor
TROP2 VAP-1 VISTA
JAK/STAT Signaling
EGFR Erythropoietin Receptor (EpoR) JAK
Pim STAT  
MAPK/ERK Pathway
ABA Receptor ERK Erythropoietin Receptor (EpoR)
JNK KLF MAP3K
MAP4K MAPKAPK2 (MK2) MEK
Microtubule‐associated serine/threonine kinase (MAST) Mixed Lineage Kinase MNK
p38 MAPK Raf Ras
Ribosomal S6 Kinase (RSK) SOS1  
Membrane Transporter/Ion Channel
Amino acid Transporter Anion Exchangers Apical Sodium-Dependent Bile Acid Transporter
Aquaporin ASCT ATP Synthase
ATP-binding cassette (ABC) transporters BCRP Calcium Channel
Calmodulin CFTR Chloride Channel
CRAC Channel CRM1 EAAT
EHD Protein FATP Ferlin Family
Ferroportin GABA Receptor GLUT
Glycine Receptor (GlyR) GlyT HCN Channel
iGluR Monoamine Transporter Monocarboxylate Transporter
Na+/Ca2+ Exchanger Na+/H+ Exchanger (NHE) Na+/HCO3- Cotransporter
Na+/K+ ATPase nAChR NKCC
Nucleoside Transporters OAT Oligopeptide Cotransporter
P-glycoprotein P2X Receptor Piezo Channel
Potassium Channel Proton Pump Sec61
SGLT SLC39 (Zinc Transporter) Sodium Channel
Sodium Chloride Cotransporter (NCC) Sodium Phosphate Cotransporter Synaptic Vesicle Proteins
TRP Channel URAT1 Urea Transporter
VDAC WNK Kinase  
Metabolic Enzyme/Protease
11β-HSD 15-PGDH 17β-HSD
3β-HSD 5 alpha Reductase Acetolactate Synthase (ALS)
Acetyl-CoA Carboxylase Acetyl-CoA synthetase ACSL Family
Acyltransferase ADAMTS Adiponectin Receptor
Aldehyde Dehydrogenase (ALDH) Aldehyde Oxidase (AO) Aldose Reductase
Amine N-methyltransferase Amino Acid Oxidase Aminoacyl-tRNA Synthetase
Aminopeptidase Aminotransferases (Transaminases) Amylases
Angiotensin-converting Enzyme (ACE) ANGPTL Apolipoprotein
Arginase ATGL ATP Citrate Lyase
Branched Chain Amino Acid Transaminase (BCAT) BTB/POZ Family Calpain
Carbamoyl Phosphate Synthetase (CPS) Carbonic Anhydrase Carbonyl Reductase
Carboxylesterase (CES) Carboxypeptidase Carnitine Palmitoyltransferase (CPT)
Carnosine-cleaving Enzyme Cathepsin Ceramidase
CETP COMT Creatine Kinase
Cryptochrome Cytochrome P450 DAGL
DGK Dihydroceramide Desaturase 1 (DES1) Dihydrofolate reductase (DHFR)
Dihydroorotate Dehydrogenase Dihydropyrimidine Dehydrogenase (DPD) Dipeptidyl Peptidase
Drug Metabolite E1/E2/E3 Enzyme Elastase
ELOVL Emopamil Binding Protein Endogenous Metabolite
Endothelin-Converting Enzyme (ECE) Enolase Enteropeptidase
Epoxide Hydrolase FAAH FABP
Factor VIIa Factor VIII Factor Xa
Factor XI Farnesyl Transferase FASTK
Fat Mass and Obesity-associated Protein (FTO) Fatty Acid Synthase (FASN) FBPase
Ferrochelatase FOXO Fructose-1,6-bisphosphate aldolase
Furin FXR Galactokinase
GGTase GHR Glucokinase
Glucose-6-Phosphate Isomerase (GPI) Glutamate Dehydrogenase (GLDH) Glutaminase
Glutathione Peroxidase Glutathione Reductase (GR) Glutathione S-transferase
Glycolate Oxidase Glycosidase Glyoxalase (GLO)
GSNOR HCV Protease Heme Oxygenase (HO)
Hemoglobin Hepcidin Herbicide
Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase
HIV Protease HMG-CoA Reductase (HMGCR) Hormone-Sensitive Lipase (HSL)
HPPD HRASLS HSP
IDE IMPDH Indoleamine 2,3-Dioxygenase (IDO)
IPK Superfamily Isocitrate Dehydrogenase (IDH) Ketohexokinase
KMO Lactate Dehydrogenase LDLR
Lipase Lipocalin Family Liposome
Lipoxygenase LOX-1 LXR
MAGL Malate Dehydrogenase (MDH) Malonyl-CoA Decarboxylase
MALT1 MetAP Methionine Adenosyltransferase (MAT)
Methylenetetrahydrofolate Dehydrogenase (MTHFD) Microsomal Triglyceride Transfer Protein (MTP) Mineralocorticoid Receptor
Mitochondrial Metabolism Mitogen- and Stress-Activated Protein Kinase (MSK) MMP
N-myristoyltransferase NADH Dehydrogenase NADPH Oxidase
NAMPT NEDD8-activating Enzyme Neprilysin
Ornithine decarboxylase (ODC) Oxidative Phosphorylation Oxysterol-binding Protein-related Protein (ORP)
PAI-1 PANK Pantetheinase
PASK/STK37 PCSK9 PDHK
PDI PEPCK Peroxidase Enzyme
PGC-1α Phosphatase Phosphodiesterase (PDE)
Phosphoglycerate Dehydrogenase (PHGDH) Phosphoglycerate Kinase (PGK) Phospholipase
Phosphomannose Isomerase (PMI) Phosphorylase Photosystem II
PI4P5K PI5P4K Plasminogen/Plasmin
PNPLA3 PPAR Procollagen C Proteinase
Prolyl Endopeptidase (PREP) Proteasome Protein Prenyltransferase
Proteolytic Enzyme Protoporphyrinogen IX oxidase Pyruvate Carboxylase (PC)
Pyruvate Kinase Quinone Reductase RAR/RXR
Reactive Oxygen Species (ROS) Renin REV-ERB
RIO Kinase ROR RPE65
S-adenosylhomocysteine hydrolase (SAHH) Ser/Thr Kinase Ser/Thr Protease
Serine Racemase (SR) Serpin Sex Pheromone
SGK SHMT Sialyltransferase
SnRK SPFH Protein Superfamily Squalene Monooxygenase
Stearoyl-CoA Desaturase (SCD) Steroid Sulfatase Succinate Dehydrogenase
SULT Thrombin TLK
TMPRSS6 Transglutaminase Transketolase
TrxR Tryptophan Hydroxylase TSSK
Tyrosinase Tyrosine Hydroxylase UGT
Xanthine Oxidase β-glucuronidase γ-Glutamyl Transferase (GGT)
Neuronal Signaling
5-HT Receptor AAK1 Adrenergic Receptor
Amino Acid Decarboxylase Amyloid-β Beta-secretase
Calcineurin Calcium Channel CaMK
Cannabinoid Receptor CGRP Receptor Cholecystokinin Receptor
Choline Kinase Cholinesterase (ChE) COMT
Dihydroceramide Desaturase 1 (DES1) Dimethylargininase (DDAH) FAAH
GABA Receptor Glucosylceramide Synthase (GCS) GlyT
GPR119 GPR139 GPR55
Histamine Receptor Huntingtin iGluR
Imidazoline Receptor Legumain mAChR
MCHR1 (GPR24) Melanocortin Receptor Melatonin Receptor
mGluR Monoamine Oxidase nAChR
Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor
Notch OGA OGT
Olfactory Receptor OLIG2 Opioid Receptor
Orexin Receptor (OX Receptor) PINK1/Parkin Prion Protein
Serotonin Transporter Sigma Receptor Slit Proteins
Somatostatin Receptor Tau Protein Transthyretin (TTR)
Trk Receptor TRP Channel TSPO
α-synuclein γ-secretase  
NF-κB
IKK Keap1-Nrf2 MALT1
Microtubule‐associated serine/threonine kinase (MAST) NF-κB RANKL/RANK
Reactive Oxygen Species (ROS)    
PI3K/Akt/mTOR
Akt AMPK ATM/ATR
DNA-PK Erythropoietin Receptor (EpoR) GSK-3
IPK Superfamily MELK Microtubule‐associated serine/threonine kinase (MAST)
mTOR PDK-1 PI3K
PI4K PIKfyve PIN1
PTEN    
PROTAC
ATTECs AUTACs AUTOTACs
ByeTAC DUBTACs E3 Ligase Ligand-Linker Conjugates
Hsp-targeting Chimeras HyT Ligands for E3 Ligase
Ligands for Target Protein for PROTAC LYTACs Molecular Glues
PhosTACs PROTAC Linkers PROTAC-Linker Conjugates for PAC
PROTACs Proteasome Cap Targeting Chimeras RIBOTAC
SNIPERs Target Protein Ligand-Linker Conjugates  
Protein Tyrosine Kinase/RTK
Ack1 Anaplastic lymphoma kinase (ALK) Bcr-Abl
BMX Kinase BRK Btk
c-Fms c-Kit c-Met/HGFR
Discoidin Domain Receptor DYRK EGFR
Ephrin Receptor FAK FGFR
FLT3 GDNF Receptor IGF-1R
Itk JAK PDGFR
Pyk2 RET ROS Kinase
SHP1 SHP2 Src
Syk TAM Receptor Tie
TNK1 Trk Receptor VEGFR
Stem Cell/Wnt
BMI1 Casein Kinase Connective Peptide
ERK Gli GSK-3
Hedgehog Hippo (MST) JAK
Large Tumor Suppressor (LATS) Notch Oct3/4
Organoid PKA PKG
Porcupine ROCK RUNX
SDCBP sFRP-1 Smo
STAT TGF-beta/Smad Wnt
YAP β-catenin γ-secretase
TGF-beta/Smad
Dan family PKA PKC
ROCK RUNX TGF-beta/Smad
TGF-β Receptor    
Vitamin D Related/Nuclear Receptor
Androgen Receptor Constitutive Androstane Receptor Estrogen Receptor/ERR
Glucocorticoid Receptor LXR Mineralocorticoid Receptor
Nuclear Hormone Receptor 4A/NR4A Orphan Nuclear Receptor PPAR
Pregnane X Receptor (PXR) Progesterone Receptor RAR/RXR
REV-ERB ROR Thyroid Hormone Receptor
VD/VDR VKOR  
Others
Amino Acid Derivatives Biochemical Assay Reagents Drug Derivative
Drug Intermediate Drug Isomer Environmental Pollutants
Fluorescent Dye Insecticide Isotope-Labeled Compounds
MOFs mRNA Phosphoramidites
Phytohormone Reference Standards Others