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Isoforms Recommended:	Estrogen receptor

Results for "

estrogen-receptor-

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (322) Cardiovascular Disease (18) Endocrinology (101) Infection (30) Inflammation/Immunology (37) Metabolic Disease (42) Neurological Disease (39)
Click Chemistry:	Labeling and Fluorescence Imaging (1) PROTAC Synthesis (1) Azide (3) Alkynes (4)
Oligonucleotides:	Cholesterol (1)

455

Inhibitors & Agonists

Fluorescent Dyes

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Isotope-Labeled Compounds

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Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-138642

Vepdegestrant 5+ Cited Publications ARV-471	PROTACs Estrogen Receptor/ERR	Cancer
Vepdegestrant (ARV-471) is an orally active PROTAC *estrogen receptor* degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC₅₀) of about 2 nM .

HY-N2371

27-Hydroxycholesterol 5+ Cited Publications 27-OHC	Estrogen Receptor/ERR LXR Endogenous Metabolite	Cancer
27-Hydroxycholesterol (27-OHC) is a selective *estrogen receptor* modulator and an agonist of the liver X receptor.

HY-103456

PHTPP 25+ Cited Publications	Estrogen Receptor/ERR	Cancer
PHTPP is a selective estrogen receptor β (ERβ) antagonist with 36-fold selectivity over ERα .

HY-103449

G15 35+ Cited Publications	Estrogen Receptor/ERR	Cancer
G15 is a high affinity and selective *G-protein-coupled estrogen receptor* (GPER/GPR30) antagonist with a K_i** of 20 nM .

HY-B0463

Clomiphene citrate 5 Publications Verification Clomifene citrate	Estrogen Receptor/ERR	Neurological Disease Endocrinology Cancer
Clomiphene citrate (Clomifene citrate) is an orally active estrogen-receptor modulator. Clomiphene citrate has anti-cancer actixity, induces perturbations during meiotic maturation and cytogenetic abnormalities and ameliorates in managing psychiatric and cognitive impairment .

HY-100583

(-)-(S)-Equol 2 Publications Verification	Estrogen Receptor/ERR Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
(-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a K_i of 0.73 nM.

HY-100689

Propyl pyrazole triol 15+ Cited Publications PPT	Estrogen Receptor/ERR	Cancer
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .

HY-B0005A

Toremifene 5+ Cited Publications Z-Toremifene; NK 622 free base; FC-1157a free base	Estrogen Receptor/ERR	Infection Cancer
Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively .

HY-12870

AZD9496 25+ Cited Publications	Estrogen Receptor/ERR	Cancer
AZD9496 is an effective, selective estrogen receptor (ERα) antagonist with an IC₅₀ of 0.28 nM. AZD9496 is an orally active, selective estrogen receptor degrader (SERD).

HY-B0005

Toremifene citrate 5+ Cited Publications Z-Toremifene citrate; NK 622; FC-1157a	Estrogen Receptor/ERR Apoptosis	Infection Cancer
Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 μM and 2.6 μM, respectively .

HY-B1100

Estradiol cypionate 10+ Cited Publications	Estrogen Receptor/ERR Apoptosis	Endocrinology Cancer
Estradiol cypionate is the 17β-cypionate ester of Estradiol, which inhibits ET-1 synthesis by acting on estrogen receptors .

HY-12864

Brilanestrant 5+ Cited Publications ARN-810; GDC-0810	Estrogen Receptor/ERR	Cancer
Brilanestrant (ARN-810; GDC-0810) is an orally bioavailable *selective estrogen receptor* degrader (SERD) with IC₅₀** of 0.7 nM.

HY-13724B

Pipendoxifene hydrochloride	Estrogen Receptor/ERR	Cancer
Pipendoxifene hydrochloride is a selective *estrogen receptor* modulator (SERM) that can be used for the research of breast cancer .

HY-101271

WAY-200070 1 Publications Verification	Estrogen Receptor/ERR	Neurological Disease
WAY-200070 is a selective estrogen receptor β (ERβ) agonist with an IC₅₀ of 2.3 nM.

HY-111486

LSZ-102 1 Publications Verification	Estrogen Receptor/ERR	Cancer
LSZ-102 is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) with an IC₅₀ value of 0.2 nM.

HY-N0553

Gypenoside XVII 3 Publications Verification Gynosaponin S	Estrogen Receptor/ERR Endogenous Metabolite	Cardiovascular Disease
Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate *estrogen receptors*.

HY-126109

(±)-8-Prenylnaringenin	Estrogen Receptor/ERR Apoptosis	Metabolic Disease Endocrinology Cancer
(±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen. (±)-8-Prenylnaringenin is an orally active selective estrogen receptor modulator (SERM) (Estrogen Receptor/ERR) that inhibits ERα and ERβ with IC₅₀s of 57 nM and 68 nM, respectively. (±)-8-Prenylnaringenin has anticancer effects, and can be used for osteoporosis research .

HY-16950B

(E)-4-Hydroxytamoxifen (E)-Afimoxifene	Estrogen Receptor/ERR	Cancer
(E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an *estrogen receptor* modulator.

HY-112627

CAY 10465 1 Publications Verification	Aryl Hydrocarbon Receptor	Cardiovascular Disease
CAY 10465 is a selective and high-affinity AhR agonist, with a K_i of 0.2 nM, and shows no effect on estrogen receptor (K_i >100000 nM).

HY-W654077

Bisphenol AF-d4 BPAF-d₄; 4,4'-(Perfluoropropane-2,2-diyl)diphenol-d₄	Estrogen Receptor/ERR	Endocrinology
Bisphenol AF-d₄ is the isotope labelled analog of Bisphenol AF (HY-W013782). Bisphenol AF is a full agonist for the estrogen receptor. Bisphenol AF acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor Era. Bisphenol AF-d₄ can be used for the research of endocrinology and cancer .

HY-111484

GDC-0927 3 Publications Verification SRN-927	Estrogen Receptor/ERR	Cancer
GDC-0927 (SRN-927) is a potent, non-steroidal, orally bioavailable, selective *estrogen receptor* antagonist .

HY-110201

Estrogen receptor modulator 1	Estrogen Receptor/ERR	Cancer
Estrogen receptor modulator 1 (compound 18) is an orally active and selective *estrogen receptor* modulator (SERM), with a pIC₅₀ of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors .

HY-W1006471

Estrogen receptor-agonist-1	Estrogen Receptor/ERR	Endocrinology
Estrogen receptor-agonist-1 (compound 4e) is a estrogen receptor (ER) agonist that binds to ERα with high affinity .

HY-150601

Estrogen receptor-IN-1 1 Publications Verification	Estrogen Receptor/ERR	Metabolic Disease
Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC₅₀s of 13, 5µM for ERα and Erβ, respectively .

HY-13724

Pipendoxifene ERA-923	Estrogen Receptor/ERR	Cancer
Pipendoxifene is a selective *estrogen receptor* modulator (SERM).

HY-145341

GNE-149	Estrogen Receptor/ERR	Cancer
GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα; IC₅₀=0.053 nM). GNE-149 is a selective estrogen receptor degrader (SERD). GNE-149 can be used for the research of breast cancer .

HY-U00178

Idoxifene CB7432	Estrogen Receptor/ERR	Cancer
Idoxifene (CB7432) is a novel tissue-specific selective *estrogen receptor* modulator (SERM).

HY-150693

Estrogen receptor β antagonist 2	Estrogen Receptor/ERR	Cancer
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC₅₀s of 109.10, 0.63 µM for Erα and Erβ, respectively .

HY-B0463R

Clomiphene citrate (Standard) Clomifene citrate (Standard)	Reference Standards Estrogen Receptor/ERR	Neurological Disease Endocrinology Cancer
Clomiphene (citrate) (Standard) is the analytical standard of Clomiphene (citrate). This product is intended for research and analytical applications. Clomiphene citrate (Clomifene citrate) is an orally active estrogen-receptor modulator. Clomiphene citrate has anti-cancer actixity, induces perturbations during meiotic maturation and cytogenetic abnormalities and ameliorates in managing psychiatric and cognitive impairment .

HY-B0412S

Estriol-d2	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estriol-d₂ is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B0412S2

Estriol-d3	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estriol-d₃ is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-N2371R

27-Hydroxycholesterol (Standard) 27-OHC (Standard)	Reference Standards Estrogen Receptor/ERR LXR Endogenous Metabolite	Cancer
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

HY-13636B

Fulvestrant (R enantiomer) ICI 182780 (R enantiomer); ZD 9238 (R enantiomer); ZM 182780 (R enantiomer)	Estrogen Receptor/ERR	Cancer
Fulvestrant R enantiomer (ICI 182780 R enantiomer) is the R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC₅₀ of 9.4 nM.

HY-117153

GW7604	Estrogen Receptor/ERR	Cancer
GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist .

HY-150692

Estrogen receptor α antagonist 1	Estrogen Receptor/ERR	Cancer
Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, with IC₅₀s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively. Estrogen receptor α antagonist 1 can be used for the research of cancer .

HY-151230

(-)-Erteberel	Estrogen Receptor/ERR	Cancer
(-)-Erteberel is a selective estrogen receptor beta (ERβ) agonist. (-)-Erteberel can be utilized in the study of diseases mediated by estrogen receptor beta (ERβ), such as prostate cancer .

HY-138642S

Vepdegestrant-d5 ARV-471-d₅	Isotope-Labeled Compounds	Cancer
Vepdegestrant-d₅ (ARV-471-d₅) is the deuterium labeled Vepdegestrant (HY-138642). Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC₅₀ of about 2 nM .

HY-B0412S3

Estriol-13C3 Oestriol-¹³C₃	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estriol- ¹³C₃ is the ¹³C-labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-111484A

GDC-0927 Racemate SRN-927 Racemate	Estrogen Receptor/ERR	Cancer
GDC-0927 Racemate (SRN-927 Racemate) is an estrogen receptor (ER) degrader that can effectively inhibit the activity of ER-α with an IC₅₀ value of 0.2 nM and can be used in diseases related to estrogen receptors.

HY-110392

CMP8	Estrogen Receptor/ERR	Cancer
CMP8, a selective ligand for *estrogen receptor, binds to the mutant estrogen receptor* ligand binding domain (ERLBD). CMP8 exhibits IC₅₀ values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively .

HY-138642A

(Rac)-Vepdegestrant (Rac)-ARV-471	Estrogen Receptor/ERR PROTACs	Cancer
(Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC *estrogen receptor* degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC₅₀) of about 2 nM .

HY-19468

ERB-196 WAY-202196	Estrogen Receptor/ERR	Neurological Disease Inflammation/Immunology
ERB-196 is a nonsteroidal selective *estrogen receptor-β* (ERβ) agonist.

HY-100327

MK-6913 Tetrahydrofluoroene 52	Estrogen Receptor/ERR	Metabolic Disease
MK-6913 (Tetrahydrofluoroene 52) is a potent and selective estrogen receptor β agonist.

HY-135324

4,4'-Iminodiphenol	Estrogen Receptor/ERR	Endocrinology
4-Propionamidophenol (compound 4a) is an inactive estrogen receptor ligand based on the diphenylamine skeleton .

HY-124114

4-Hydroxytoremifene 4-OH-TOR	Estrogen Receptor/ERR	Endocrinology
4-Hydroxytoremifene (4-OH-TOR) is an estrogen receptor antagonist that blocks the uterus's ability to absorb estradiol .

HY-N2448

Lindleyin	Estrogen Receptor/ERR	Endocrinology
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity .

HY-19822S

Elacestrant-d4 RAD1901-d₄	Isotope-Labeled Compounds Estrogen Receptor/ERR	Cancer
Elacestrant-d₄ (RAD1901-d₄) is a deuterated labeled Elacestrant (HY-19822). Elacestrant (RAD1901) is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-144204

Estrogen receptor antagonist 5	Estrogen Receptor/ERR	Endocrinology Cancer
Estrogen receptor antagonist 5 is a potent antagonist of *Estrogen receptor. The estrogen receptor* is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 5 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 165) .

HY-144206

Estrogen receptor antagonist 6	Estrogen Receptor/ERR	Endocrinology
Estrogen receptor antagonist 6 is a potent antagonist of *Estrogen receptor. The estrogen receptor* is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 6 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 166) .

HY-143253

Estrogen receptor antagonist 7	Estrogen Receptor/ERR	Cancer
Estrogen receptor antagonist 7 (compound 13) is a potent estrogen receptors (ER) antagonist. Estrogen receptor antagonist 7 has antiproliferative activity against breast and ovarian cancer cells. Anticancer and anti-uterotrophic activities .

Cat. No.	상품명	Type

HY-W011927

4,4'-Sulfonyldiphenol

Bisphenol S; Bis(4-hydroxyphenyl) sulfone

Biochemical Assay Reagents

4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae .

HY-W011927R

4,4'-Sulfonyldiphenol (Standard)

Bisphenol S (Standard); Bis(4-hydroxyphenyl) sulfone (Standard)

Biochemical Assay Reagents

4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

Cat. No.	상품명	Target	Research Area

HY-W142080

α-Methyl-DL-tryptophan α-Methyltryptophan	mTOR Autophagy Apoptosis Amino Acid Derivatives	Metabolic Disease Cancer
α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight .

HY-P5464

SRC-1 NR box peptide	Estrogen Receptor/ERR	Others
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands .

HY-P5464A

SRC-1 NR box peptide acetate	Estrogen Receptor/ERR	Endocrinology
SRC-1 NR box peptide acetate is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide acetate can be used to study the regulatory mechanisms of estrogen receptor ligands .

HY-P11153

HGH fragment 176-191	Estrogen Receptor/ERR	Cancer
HGH fragment 176-191 is a fragment of Human Growth Hormone. HGH fragment 176-191 binds with high affinity to Ki-67, MiB protein, and the *estrogen* receptor. HGH fragment 176-191 enhances the toxicity of Doxorubicin (HY-15142A)-loaded Chitosan nanoparticles against breast cancer .

HY-P3833

Yp537 Anti-estrogen	Estrogen Receptor/ERR	Endocrinology
Yp537 is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor .

HY-P10843

R4K1	Estrogen Receptor/ERR	Cancer
R4K1 is a cell-permeable stapled peptide. R4K1 binds to the estrogen receptor (ER) α with high affinity and inhibits its interaction with coactivators. R4K1 can enter breast cancer cells to regulate gene transcription and inhibit cell proliferation. R4K1 can be used in the study of cancer .

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models .

HY-P3833A

Yp537 TFA Anti-estrogen TFA	Estrogen Receptor/ERR	Endocrinology
Yp537 TFA is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-14590

Kaempferol Maximum Cited Publications 76 Publications Verification Kempferol; Robigenin	Flavonols Classification of Application Fields Anti-aging Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms other families Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 3 Publications Verification Afimoxifene; 4-OHT	Alkaloids Monophenols Classification of Application Fields Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective *estrogen receptor* modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-N2371

27-Hydroxycholesterol 5+ Cited Publications 27-OHC	Structural Classification Classification of Application Fields Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Steroids Source Classification Cancer	Estrogen Receptor/ERR LXR Endogenous Metabolite
27-Hydroxycholesterol (27-OHC) is a selective *estrogen receptor* modulator and an agonist of the liver X receptor.

HY-N0377

Liquiritigenin 10+ Cited Publications 4',7-Dihydroxyflavanone	Neurological Disease Classification of Application Fields Plants Flavonoids Microorganisms Leguminosae Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch. Source Classification	Estrogen Receptor/ERR
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-13738A

Raloxifene hydrochloride 15+ Cited Publications Keoxifene hydrochloride; LY156758; LY139481 hydrochloride	Alkaloids Piperidine Alkaloids Classification of Application Fields Rutaceae Phenols Polyphenols Plants Disease Research Fields Tetradium ruticarpum (A. Jussieu) T. G. Hartley Endocrinology Source Classification Cancer	Estrogen Receptor/ERR Autophagy
Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active *estrogen receptor* modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

HY-100583

(-)-(S)-Equol 2 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavanols Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Estrogen Receptor/ERR Endogenous Metabolite
(-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a K_i of 0.73 nM.

HY-N0250

Saikosaponin D 5+ Cited Publications	Infection Triterpenes Classification of Application Fields Terpenoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	STAT NF-κB Estrogen Receptor/ERR Bacterial
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates *estrogen receptor-β*.

HY-N0835

(20S)-Protopanaxatriol 1 Publications Verification 20(S)-APPT; g-PPT	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the *glucocorticoid receptor* (GR)** and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N0233

Bavachin 10+ Cited Publications Corylifolin	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR
Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC₅₀s of 320 and 680 nM, respectively.

HY-B0412

Estriol 5 Publications Verification Oestriol	Monophenols Immune System Disorder Classification of Application Fields Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer Source Classification	Estrogen Receptor/ERR Endogenous Metabolite
Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects .

HY-14590R

Kaempferol (Standard) Maximum Cited Publications 76 Publications Verification Kempferol(Standard); Robigenin (Standard)	Classification of Application Fields Anti-aging Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Sunscreen Phenols Cosmetic Research Disease Research Fields Source Classification Cancer	Reference Standards Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite
Kaempferol (Standard) is the analytical standard of Kaempferol. This product is intended for research and analytical applications. Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

HY-15731

Estetrol	Cardiovascular Disease Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Steroids Source Classification	Estrogen Receptor/ERR Endogenous Metabolite NO Synthase
Estetrol, an orally active estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear *estrogen receptor* modulator. Estetrol binds ERα as well as ERβ (with a fourfold lower affinity). Estetrol increases eNOS expression/activity and NO synthesis in endothelial cells. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast. Estetrol can be used in contraception and menopausal hormone research .

HY-B1100

Estradiol cypionate 10+ Cited Publications	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR Apoptosis
Estradiol cypionate is the 17β-cypionate ester of Estradiol, which inhibits ET-1 synthesis by acting on estrogen receptors .

HY-W013935

Bisphenol B	Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species (ROS)
Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

HY-W014589

2,4-Di-tert-butylphenol 2 Publications Verification 2,4-DTBP	Monophenols Microorganisms Classification of Application Fields Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Fungal Apoptosis RAR/RXR Amyloid-β
2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .

HY-N6714

Alternariol	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-N0553

Gypenoside XVII 3 Publications Verification Gynosaponin S	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Endogenous metabolite Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification	Estrogen Receptor/ERR Endogenous Metabolite
Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate *estrogen receptors*.

HY-126109

(±)-8-Prenylnaringenin	Structural Classification Flavonoids Humulus lupulus L. Flavonones Plants Moraceae Source Classification	Estrogen Receptor/ERR Apoptosis
(±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen. (±)-8-Prenylnaringenin is an orally active selective estrogen receptor modulator (SERM) (Estrogen Receptor/ERR) that inhibits ERα and ERβ with IC₅₀s of 57 nM and 68 nM, respectively. (±)-8-Prenylnaringenin has anticancer effects, and can be used for osteoporosis research .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and *estrogen receptors* in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Cardiovascular Disease Monophenols other families Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to *estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase*. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-N0910

Notoginsenoside Ft1 1 Publications Verification	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	PI3K mTOR Akt Apoptosis p38 MAPK ERK Transmembrane Glycoprotein Glutathione Reductase (GR) Estrogen Receptor/ERR Calcium Channel Ferroptosis G protein-coupled Bile Acid Receptor 1 FXR
Notoginsenoside Ft1 is an orally active bioactive saponin. Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8 ⁺ T cells, thereby inducing apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis. Notoginsenoside Ft1 causes vasodilation by activating glucocorticoid receptors (GR) and estrogen receptor beta (ERβ) in endothelial cells. Notoginsenoside Ft1 increases intracellular Ca ²⁺ accumulation, reduces cAMP levels by activating a signaling network mediated through P2Y₁₂ receptors, and promotes platelet aggregation, thereby exerting a procoagulant effect. Notoginsenoside Ft1 inhibits ferroptosis (ferroptosis) in renal tubular epithelial cells by activating the TGR5 receptor, thereby demonstrating a renal protective effect. Notoginsenoside Ft1 acts as a TGR5 agonist and an FXR antagonist to combat obesity and insulin resistance .

HY-N4121

Isocurcumenol 1 Publications Verification	other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR Apoptosis
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

HY-N10403

4-Hydroxyestradiol 1 Publications Verification 4-Hydroxy-17β-estradiol	Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Drug Metabolite Endogenous Metabolite
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a K_i of 0.48 nM .

HY-125703

Ferutinin	Viguiera dentata (Cav.) Spreng. Infection Classification of Application Fields Terpenoids Sesquiterpenes Umbelliferae Plants Disease Research Fields Endocrinology Source Classification Cancer	Estrogen Receptor/ERR Apoptosis
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca ²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .

HY-100583R

(-)-(S)-Equol (Standard)	Structural Classification Flavonoids Flavanols Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
(-)-(S)-Equol (Standard) is the analytical standard of (-)-(S)-Equol. This product is intended for research and analytical applications. (-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.

HY-13738AR

Raloxifene hydrochloride (Standard) 5+ Cited Publications Keoxifene hydrochloride(Standard); LY156758(Standard); LY139481 hydrochloride (Standard)	Alkaloids Classification of Application Fields Rutaceae Phenols Plants Disease Research Fields Tetradium ruticarpum (A. Jussieu) T. G. Hartley Endocrinology Source Classification Cancer	Reference Standards Estrogen Receptor/ERR Autophagy
Raloxifene (hydrochloride) (Standard) is the analytical standard of Raloxifene (hydrochloride). This product is intended for research and analytical applications. Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active *estrogen receptor* modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

HY-N2026A

Propylparaben sodium 1 Publications Verification Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium	Infection Structural Classification Natural Products Classification of Application Fields Cosmetic Research Endogenous metabolite Disease Research Fields Source Classification	Estrogen Receptor/ERR
Propylparaben sodium is an orally active weak estrogen receptor agonist. Propylparaben sodium regulates the PI3K-AKT and JNK signaling pathways, induces oxidative stress, and alters the estrous cycle, hormone levels and ovarian reserve function. Propylparaben sodium inhibits the growth of antral follicles and alters the accumulation of steroid hormones in follicle culture media. Propylparaben sodium can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury[1][2][3][4][5].

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Animals Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

HY-W014589R

2,4-Di-tert-butylphenol (Standard) 2,4-DTBP (Standard)	Structural Classification Monophenols Microorganisms Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Fungal Apoptosis RAR/RXR Amyloid-β
2,4-Di-tert-butylphenol (Standard) is the analytical standard of 2,4-Di-tert-butylphenol (HY-W014589). This product is intended for research and analytical applications. 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities, and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of pharmaceuticals and fragrances .

HY-N2371R

27-Hydroxycholesterol (Standard) 27-OHC (Standard)	Structural Classification Natural Products Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Estrogen Receptor/ERR LXR Endogenous Metabolite
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

HY-N11785

Glyceollin I	Structural Classification Monophenols Leguminosae Glycine max (L.) merr Phenols Plants Source Classification	Estrogen Receptor/ERR
Glyceollin I is a selective estrogen receptor (ER) modulator with anticancer, antioxidant, and anti-inflammatory activities. Glyceollin I is promising for research of estrogen-related cancers (e.g., breast, ovarian) and metabolic disorders (e.g., hypercholesterolemia) .

HY-N6052

(+)-Medicarpin	Monophenols other families Classification of Application Fields Terpenoids Phenols Diterpenoids Plants Disease Research Fields Cancer Source Classification	Estrogen Receptor/ERR
(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action .

HY-Z12208

N1-Phenylsuberamide	Structural Classification Microorganisms Terpenoids Diterpenoids Source Classification	Drug Derivative
N1-Phenylsuberamide is an organic amide compound, and its structure can be regarded as a simplified analogue of Vorinostat (HY-10221). N1-Phenylsuberamide exhibits moderate anti-proliferative activity against MDA-MB-231 and MCF-7 cells. N1-Phenylsuberamide does not show significant HDAC inhibitory activity and can only weakly induce the expression of the p21 gene. N1-Phenylsuberamide has extremely low relative binding affinity of estrogen receptor. N1-Phenylsuberamide can be used as a control compound .

HY-N2448

Lindleyin	Classification of Application Fields Rheum palmatum L. Polygonaceae Phenols Polyphenols Plants Disease Research Fields Endocrinology Source Classification	Estrogen Receptor/ERR
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity .

HY-N2682B

Dehydrodiconiferyl alcohol	Monophenols Cucurbita moschata Cucurbitaceae Phenols Plants Source Classification	Estrogen Receptor/ERR
Dehydrodiconiferyl alcohol is an *estrogen receptor* agonist that can promote BMP-2-induced osteoblastogenesis. Dehydrodiconiferyl alcohol also exerts anti-inflammatory activity through inactivation of NF-κB pathways .

HY-N12023

Deacetylnomilin	Triterpenes Natural Products Terpenoids Rutaceae Plants Citrus reticulata Blanco Source Classification	Bacterial Fungal
Deacetylnomilin can be isolated from Citrus reticulata and has antibacterial and antifungal activity. Deacetylnomilin is a potent inhibitor of cell proliferation with an IC₅₀ value of 0.005 ug/mL against estrogen receptor-positive (ER+) cells .

HY-N0250R

Saikosaponin D (Standard)	Triterpenes Structural Classification Terpenoids Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Reference Standards STAT NF-κB Estrogen Receptor/ERR Bacterial
Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-16950AR

(E/Z)-4-Hydroxytamoxifen (Standard) Afimoxifene (Standard); 4-OHT (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Source Classification	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
(E/Z)-4-Hydroxytamoxifen (Standard) is the analytical standard of (E/Z)-4-Hydroxytamoxifen. This product is intended for research and analytical applications. (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective *estrogen receptor* modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-B0652R

Etonogestrel (Standard) 3-Oxodesogestrel (Standard); 3-keto-Desogestrel (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Metabolite Reference Standards Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-125037

Diptoindonesin G	Structural Classification Phenols Polyphenols Plants Dipterocarpaceae Source Classification	Estrogen Receptor/ERR HSP
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of *estrogen receptor* and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC₅₀ of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer .

HY-121351

Inokosterone	other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Estrogen Receptor/ERR
Inokosterone is a potential agent target of estrogen receptor 1 in rheumatoid arthritis patients .

HY-N1556

Psidial A	Natural Products Psidium guajava Linn. Myrtaceae Plants Source Classification	Estrogen Receptor/ERR
Psidial A is an epimer of sesquiterpenoid-diphenylmethane meroterpenoid. Psidial A may act as a selective estrogen receptors modulator. Psidial A also has potential for anticancer research .

HY-N0553R

Gypenoside XVII (Standard) Gynosaponin S (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Endogenous metabolite Gynostemma pentaphyllum (Thunb.) Makino Source Classification	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
Gypenoside XVII (Standard) is the analytical standard of Gypenoside XVII. This product is intended for research and analytical applications. Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors.

HY-N8170

4',2-Dihydroxy-4,6-dimethoxydihydrochalcone	other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Plants Disease Research Fields Endocrinology Source Classification	Estrogen Receptor/ERR
4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an *estrogen* agonist, shows binding affinity for bovine uterine estrogen receptor with an IC₅₀50 of 15 μM .

HY-N9329

Glicoricone	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones Source Classification	Monoamine Oxidase Estrogen Receptor/ERR
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity .

HY-N0233R

Bavachin (Standard) Corylifolin (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Source Classification	Reference Standards Estrogen Receptor/ERR
Bavachin (Standard) is the analytical standard of Bavachin. This product is intended for research and analytical applications. Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively.

HY-N15531

Icariside D1	Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides Source Classification	Estrogen Receptor/ERR
Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of *estrogen receptors*. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers .

HY-107803

Geranium oil	Natural Products Plants Geraniaceae Source Classification	Estrogen Receptor/ERR
Geranium oil serves as a partial agonist for estrogen receptor (ER), enhancing both the cytotoxicity induced by Tamoxifen (TMX) (HY-13757A) in GT1-7 cells and the adverse effects of TMX on the central nervous system. Geranium oil can be utilized in the research of neurological disorders such as dementia .

HY-N6678R

Zearalanone (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Antibacterial Disease Research Anticancer Source Classification	Reference Standards Estrogen Receptor/ERR
Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-N0835R

(20S)-Protopanaxatriol (Standard) 20(S)-APPT (Standard); g-PPT (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

Recombinant Proteins Recommended:

Estrogen Receptor

Species:	Human (3)
Tag:	His (3)
Source:	E. coli (3)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P70248

	ER alpha/ESR1 Protein, Human (His) 1 Publications Verification rHuestrogen receptor/ER alpha, His; estrogen receptor; ER; ER-Alpha; Estradiol receptor; Nuclear receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1	Human	E. coli
	The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704047

	GSDME Protein, Human (His) Inversely correlated with estrogen receptor expression 1	Human	E. coli
	GSDME Protein, Human (His) is the recombinant human-derived GSDME protein, expressed by E. coli, with N-6*His tag.

HY-P70791

	ER beta/ESR2 Protein, Human (His) estrogen receptor Beta; ER-Beta; Nuclear receptor Subfamily 3 Group A Member 2; ESR2; ESTRB; NR3A2	Human	E. coli
	ER beta/ESR2 Protein, a nuclear hormone receptor, binds estrogens akin to ESR1/ER-alpha. It activates estrogen-dependent reporter genes with ERE. However, it lacks ligand binding ability and exhibits minimal ERE binding, resulting in the loss of ligand-dependent transactivation ability. ER beta/ESR2 Protein, Human (His) is the recombinant human-derived ER beta/ESR2 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	상품명	Chemical Structure

HY-B0141S2

Estradiol-d5
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B0141S1

Estradiol-d4 2 Publications Verification
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-13636S

Fulvestrant-d3
Fulvestrant-d₃ is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC₅₀ of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC₅₀ of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .

HY-W011927S

4,4'-Sulfonyldiphenol-d8

1 Publications Verification

4,4'-Sulfonyldiphenol-d₈ (Bisphenol S (4,4'-Sulfonyldiphenol)-d₈) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

HY-W654077

Bisphenol AF-d4
Bisphenol AF-d₄ is the isotope labelled analog of Bisphenol AF (HY-W013782). Bisphenol AF is a full agonist for the estrogen receptor. Bisphenol AF acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor Era. Bisphenol AF-d₄ can be used for the research of endocrinology and cancer .

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity .

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B0141S5

Estradiol-13C2
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-13636S1

Fulvestrant-d5

Fulvestrant-d₅ (ICI 182780-d₅) is a isotope of Fulvestrant (HY-13636) . Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC₅₀ of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC₅₀ of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy.

HY-W749327

2,4-Di-tert-butylphenol-d21

2,4-Di-tert-butylphenol-d₂1 (2,4-DTBP-d₂1) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .

HY-B0412S

Estriol-d2
Estriol-d₂ is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B0412S2

Estriol-d3
Estriol-d₃ is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-18719ES

Endoxifen-d5
Endoxifen-d₅ is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study .

HY-16950BS

(E)-4-Hydroxytamoxifen-d5
(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an *estrogen receptor* modulator.

HY-138642S

Vepdegestrant-d5

Vepdegestrant-d₅ (ARV-471-d₅) is the deuterium labeled Vepdegestrant (HY-138642). Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC₅₀ of about 2 nM .

HY-118861S

Enclomiphene-d4 hydrochloride
Enclomiphene-d₄ ((E)-Clomiphene-d₄) hydrochloride?is a deuterium labeled Enclomiphene hydrochloride (HY-118861B). Enclomiphen hydrochloride?is a potent and orally active?estrogen receptor?antagonist with antioestrogenic property .

HY-W777284

Zeranol-d5 (mixture of diastereomers)
Zeranol-d₅ (mixture of diastereomers) is the deuterium labeled Zeranol (HY-N6709). Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity .

HY-W766497

Alpha-Zearalenol-d7
Alpha-Zearalenol-d₇ is the deuterium labeled α-Zearalenol (HY-N6710). α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER). α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .

HY-W011926S

Diisopropyl phthalate-d4
Diisopropyl phthalate-d₄ (DiPP-d₄) is the deuterium labeled Diisopropyl Phthalate (HY-W011926). Diisopropyl phthalate (DiPP) is a phthalate diester, which is widely used as an additive in plastics and consumer products. Diisopropyl phthalate has a weak binding ability to the recombinant human *estrogen receptor, with an IC₅₀* of 41000 μM .

HY-A0287S

Clomiphene-d5 hydrochloride

Clomifene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene)-d₅ hydrochloride is a deuterium labeled Clomifene hydrochloride (HY-A0287A). Clomiphene hydrochloride is an orally active ovulation-inducing agent. Clomiphene hydrochloride binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene hydrochloride can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene hydrochloride ameliorates memory impairment in PCOS models. Clomiphene hydrochloride mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene hydrochloride can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer .

HY-B0412S3

Estriol-13C3
Estriol- ¹³C₃ is the ¹³C-labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-19822S

Elacestrant-d4
Elacestrant-d₄ (RAD1901-d₄) is a deuterated labeled Elacestrant (HY-19822). Elacestrant (RAD1901) is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-118861S1

Enclomiphene-d4
Enclomiphene-d₄ ((E)-Clomiphene-d₄) is a deuterium labeled Enclomiphene. Enclomiphen?is a potent and orally active?estrogen receptor?antagonist with antioestrogenic property .

HY-B0141S4

Estradiol-13C6
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-B0652S1

Etonogestrel-d6
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-W653896

Alternariol-d2

Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-B1984S

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-B0005AS

Toremifene-d6
Toremifene-d₆ is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 μM and 2.6 μM, respectively .

HY-B0005S1

Toremifene-d6 hydrochloride
Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively .

HY-B0005S

Toremifene-d6 citrate
Toremifene-d₆ (citrate) is the deuterium labeled Toremifene citrate. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 μM and 2.6 μM, respectively .

HY-B0412S1

Estriol-d1
Estriol-d is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B0723S

Ospemifene-d4
Ospemifene-d₄ is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC₅₀ values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects .

HY-B0723S2

Ospemifene-d5
Ospemifene-d₅ (FC-1271a-d₅) is deuterium labeled Ospemifene. Ospemifene is a non-estrogen selective *estrogen receptor* modulator (SERM), with K_is of 380 and 410 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene can be used for the research of vaginal atrophy and breast cancer .

HY-19822S3

Elacestrant-d6
Elacestrant-d₆ (RAD1901-d₆) is a deuterated labeled Elacestrant (HY-19822). Elacestrant is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-W727814

Pipendoxifene-d10
Pipendoxifene-d₁₀ (ERA-923-d₁₀) is the deuterium labeled Pipendoxifene (HY-13724). Pipendoxifene is a selective estrogen receptor modulator (SERM).

HY-135582S1

Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4'-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium

Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582S

Raloxifene 4'-glucuronide-d4

Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-19822S1

Elacestrant-d4-1
Elacestrant-d₄-1 is the deuterium labeled Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively .

HY-B0316S1

Avobenzone-d3
Avobenzone-d₃ is deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an *estrogen* agonist .

HY-13738S2

Raloxifene-d4 hydrochloride
Raloxifene-d₄ (hydrochloride) is the deuterium labeled Raloxifene. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research .

HY-13738S

Raloxifene-d4
Raloxifene-d₄ is the deuterium labeled Raloxifene. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research .

HY-13738S3

Raloxifene-d10
Raloxifene-d₁₀ is the deuterium labeled Raloxifene. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research .

HY-N6710S

α-Zearalenol-d4
α-Zearalenol-d4 is a deuterated labeled α-Zearalenol . α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .

HY-15731S

Estetrol-d4
Estetrol-d₄ is the deuterium labeled Estetrol. Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast .

HY-W100026S

Galaxolide-d6 (mixture of diastereomers) (>80%)
Galaxolide-d₆ (mixture of diastereomers) (>80%) is the deuterium labeled Galaxolide (HY-W100026). Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), trigger oxidative stress and genotoxicity, and induce EROD and GST (Glutathione S-transferase) enzyme activity .

HY-B2158S

Chlorotrianisene-d9
Chlorotrianisene-d₉ is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

Host:	Mouse (5) Rabbit (9)
Reactivity:	Human (14) Rat (9) Mouse (10) Rabbit (2)
Application:	IHC-P (8) ICC/IF (9) IF-Tissue (1) IP (5) IHC-F (3) WB (14) ChIP (2) FC (4) ELISA (6)
Isotype:	IgG (9) IgG1 (2) IgG2b (3)
Conjugation:	Non-conjugated (14)
Clonality:	Polyclonal (1) Monoclonal (9) Recombinant (4)
Modification:	Unmodified (10)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P80663

	Estrogen Receptor alpha Antibody (YA450) 1 Publications Verification ESR1; Era; Eralpha; estrogen receptor; Estradiol receptor; ER-alpha; estrogen receptor 1; NR3A1; ER; ESR; ESRA; estrogen receptor alpha	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human
	Estrogen Receptor alpha Antibody (YA450) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P80662

	Estrogen Receptor alpha Antibody (YA768) ESR1; Era; Eralpha; estrogen receptor; Estradiol receptor; ER-alpha; estrogen receptor 1; NR3A1; ER; ESR; ESRA; estrogen receptor alpha	WB	Human, Mouse, Rat
	Estrogen Receptor alpha Antibody (YA768) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P80662A

	Estrogen Receptor alpha Antibody (YA768)(PBS only) ESR1; Era; Eralpha; estrogen receptor; Estradiol receptor; ER-alpha; estrogen receptor 1; NR3A1; ER; ESR; ESRA; estrogen receptor alpha	WB	Human, Mouse, Rat
	Estrogen Receptor alpha Antibody (YA768) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P80663A

	Estrogen Receptor alpha Antibody (YA450)(PBS only) ESR1; Era; Eralpha; estrogen receptor; Estradiol receptor; ER-alpha; estrogen receptor 1; NR3A1; ER; ESR; ESRA; estrogen receptor alpha	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human
	Estrogen Receptor alpha Antibody (YA450) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P810664

	*Phospho-Estrogen Receptor* alpha (Ser118) Antibody (YA9924)** ESR1; Era; Eralpha; estrogen receptor; Estradiol receptor; ER-alpha; estrogen receptor 1; NR3A1; ER; ESR; ESRA; estrogen receptor alpha	WB, ICC/IF, IF-Tissue, IHC-P	Human, Mouse
	Phospho-Estrogen Receptor alpha (Ser118) Antibody (YA9924) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Estrogen Receptor alpha (Ser118).

HY-P85799

	Estrogen Receptor beta Antibody (YA5491) estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2;	WB, ICC/IF, ELISA	Human
	Estrogen Receptor beta Antibody (YA5491) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Estrogen Receptor beta.

HY-P82147

	Estrogen Receptor beta Antibody (YA1892) ESR2; ESTRB; NR3A2; estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2	WB, IHC-P	Human
	Estrogen Receptor beta Antibody (YA1892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Estrogen Receptor beta.

HY-P86246

	Estrogen Receptor alpha Antibody (YA5938) ESR1 ESR NR3A1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Estrogen Receptor alpha Antibody (YA5938) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P83932

	Estrogen Receptor alpha Antibody (YA3629) 1 Publications Verification ER; ESR; Era; ESRA; ESTRR; NR3A1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit
	Estrogen Receptor alpha Antibody (YA3629) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P83932A

	Estrogen Receptor alpha Antibody (YA3629)(PBS only) ER; ESR; Era; ESRA; ESTRR; NR3A1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit
	Estrogen Receptor alpha Antibody (YA3629) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P86310

	DFNA5/GSDME Antibody (YA6002) DFNA5; ICERE1; Non-syndromic hearing impairment protein 5; Inversely correlated with estrogen receptor expression 1; ICERE-1	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	DFNA5/GSDME Antibody (YA6002) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DFNA5/GSDME.

HY-P81150

	GPR30 Antibody G Protein Coupled receptor 30; G-protein coupled receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen receptor; mER; Chemokine receptor-like 2; IL8-related receptor DRY12; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; Lymphocyte-derived G-protein coupled receptor; LYGPR; GPCR-BR; CEPR; CMKRL2; DRY12; GPER.	WB, IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Mouse, Rat
	GPR30 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to GPR30.

HY-P82538

	ERR alpha Antibody (YA2283) ESRRA; ERRa; ERR1; HERR1; NR3B1; Steroid hormone receptor ERR1; ERR-alpha; ERRalpha; ESRL1; estrogen receptor-like 1; estrogen-related receptor alpha	WB, IP, FC	Human, Mouse, Rat
	ERR alpha Antibody (YA2283) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERR alpha.

HY-P83728

	PGC1 alpha+beta Antibody (YA3458) LEM6 antibody; Ligand effect modulator 6 antibody; PERC antibody; Peroxisome proliferative activated receptor, gamma, coactivator 1 antibody; PGC 1 alpha antibody; PGC-1-beta antibody; PGC-1-related estrogen receptor alpha coactivator antibody; PGC1 antibody; PGC1A antibody; PGC1v antibody; PPAR gamma coactivator 1 alpha antibody; PPAR gamma coactivator-1 beta antibody; PPARGC 1 alpha antibody; PPARGC-1-beta antibody; PPARGC1 antibody; PPARGC1A antibody; Ppargc1b antibody; PRGC1_HUMAN antibody; PRGC2_HUMAN antibody;	WB	Human, Mouse, Rat
	PGC1 alpha+beta Antibody (YA3458) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGC1 alpha+beta.

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Cat. No.
Host
Reactivity
Application
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Conjugation
Clonality
Immunogen
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Gene ID
SwissProt ID
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Formulation
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Cat. No.	상품명		Classification

HY-B0390

Mestranol		Alkynes
Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders. Mestranol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151744

N3-TFBA-O2Oc		Labeling and Fluorescence Imaging Azide
N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λ_max=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers . N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133189

Bis-propargyl-PEG9		PROTAC Synthesis Alkynes
Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands . Bis-propargyl-PEG9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0390S

Mestranol-d2		Alkynes
Mestranol-d2 is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders . Mestranol-d2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0390S1

Mestranol-d4		Alkynes
Mestranol-d₄ is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders . Mestranol-d₄ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139999

LCL-PEG3-N3		Azide
LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139999A

LCL-PEG3-N3 hydrochloride		Azide
LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	상품명		Classification

HY-N2371

27-Hydroxycholesterol 5+ Cited Publications 27-OHC		Cholesterol
27-Hydroxycholesterol (27-OHC) is a selective *estrogen receptor* modulator and an agonist of the liver X receptor.

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