CHF 4227 free base
CHF 4227 free base is an orally active and selective estrogen receptor modulator (SERM) with high affinity to the human estrogen receptor-α and -β (Ki values of 0.017 nM and 0.099 nM, respectively).
For research use only. We do not sell to patients.
- CAS No.: 444643-64-5
- Formula: C30H33NO4
- Molecular Weight:471.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hERα 0.017 nM (Ki) |
hERβ 0.099 nM (Ki) |
In ovariectomized (OVX) rats treated orally for 4 weeks, CHF 4227 free basecompletely inhibits OVX effects on bone density (ED50[1].
CHF 4227 free base reduces serum cholesterol (ED50[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 444643-64-5
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Molecular Weight 471.59
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Formula C30H33NO4
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SMILES
OC1=CC=C2C(CC3=CC=C(OCCN4CCCCC4)C=C3)=C(C5=CC=C(OC)C=C5)COC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Elisabetta Galbiati, et al. Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen. J Pharmacol Exp Ther. 2002 Oct;303(1):196-203. [Content Brief]
[2]. Maurizio Civelli, et al. Single and multiple ascending dose studies of a novel tissue-selective oestrogen receptor modulator, CHF 4227, in healthy postmenopausal women. Br J Clin Pharmacol. 2007 Sep;64(3):304-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHF 4227 free base Related Classifications
HY-107045 Related Classifications
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