444643-64-5
444643-64-5
Chemical Structure
CHF 4227 free base
- CAS No.: 444643-64-5
- Formula:C30H33NO4
- Molecular Weight:471.59
IUPAC Name: 3-(4-methoxyphenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)benzyl)-2H-chromen-7-ol
InChIKey: ZUDXUNPSRMREOJ-UHFFFAOYSA-N
SMILES: OC1=CC=C2C(CC3=CC=C(OCCN4CCCCC4)C=C3)=C(C5=CC=C(OC)C=C5)COC2=C1
Biological Activity: CHF 4227 free base is an orally active and selective estrogen receptor modulator (SERM) with high affinity to the human estrogen receptor-α and -β (Ki values of 0.017 nM and 0.099 nM, respectively)[1][2].
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CHF 4227 free base | CHF 4227 free base is an orally active and selective estrogen receptor modulator (SERM) with high affinity to the human estrogen receptor-α and -β (Ki values of 0.017 nM and 0.099 nM, respectively). | |||||||||||||||||||||
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References
- [1]. Elisabetta Galbiati, et al. Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen. J Pharmacol Exp Ther. 2002 Oct;303(1):196-203. [Content Brief]
- [2]. Maurizio Civelli, et al. Single and multiple ascending dose studies of a novel tissue-selective oestrogen receptor modulator, CHF 4227, in healthy postmenopausal women. Br J Clin Pharmacol. 2007 Sep;64(3):304-16. [Content Brief]
