Raloxifene 6-Monomethyl Ether
Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC50 of 250 nM and a pIC50 of 6.6.
For research use only. We do not sell to patients.
- CAS No.: 178451-13-3
- Formula: C29H29NO4S
- Molecular Weight:487.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
250 nM
Compound: 5b'
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Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro)
Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro)
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[PMID: 9003514] |
| MCF7 | IC50 |
250 nM
Compound: Table 6, Entry g
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Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
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[PMID: 22405286] |
Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative with a methoxy group on C6. Raloxifene 6-Monomethyl Ether holds poor ICsub>50 value because of disruption to the hydrogen bond network and steric disfavor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 178451-13-3
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Molecular Weight 487.61
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Formula C29H29NO4S
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SMILES
O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(OC)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Raloxifene 6-Monomethyl Ether Related Classifications
HY-135584 Related Classifications
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