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Estrogen receptor modulator 1 

Cat. No.: HY-110201
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Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors.

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Estrogen receptor modulator 1 Chemical Structure

Estrogen receptor modulator 1 Chemical Structure

CAS No. : 63676-22-2

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Description

Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].

In Vitro

Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation[2].
Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days[2].

Cell Proliferation Assay[2]

Cell Line: T47D:A18/PKCα and T47D:A18-TAM1 cells
Concentration: 100 nM
Incubation Time: 10 days
Result: Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation.

Cell Viability Assay[2]

Cell Line: MCF-7:5C cells
Concentration: 100 nM
Incubation Time: 9 days
Result: Significantly inhibited the growth of MCF-7:5C cells.
In Vivo

Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors[2].

Animal Model: 4-6 week old athymic mice (Harlan-Sprague-Dawley)[2]
Dosage: 1.5 mg/animal
Administration: p.o. ; daily for 2 weeks
Result: Significantly reduced tumor volume.
Molecular Weight

242.29

Formula

C₁₄H₁₀O₂S

CAS No.

63676-22-2

SMILES

OC1=CC=C(C=C(C2=CC=C(O)C=C2)S3)C3=C1

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Keywords:

Estrogen receptor modulator 1Estrogen receptor modulator1Estrogen receptor modulator-1Estrogen Receptor/ERRtumorselectiveMCF-7:5CcellsbreastcancerathymicmiceInhibitorinhibitorinhibit

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Estrogen receptor modulator 1
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HY-110201
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