63676-22-2
63676-22-2
Chemical Structure
Estrogen receptor modulator 1
- CAS No.: 63676-22-2
- Formula:C14H10O2S
- Molecular Weight:242.29
IUPAC Name: 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol
InChIKey: MDGWZLQPNOETLH-UHFFFAOYSA-N
SMILES: OC1=CC=C(C=C(C2=CC=C(O)C=C2)S3)C3=C1
Biological Activity: Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].
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Estrogen receptor modulator 1 | 99.91% | Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors. | ||||||||||||||||||||
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References
- [1]. Brogi S, et al. 3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors. Eur J Med Chem. 2013 Sep;67:344-51. [Content Brief]
- [2]. Molloy ME, et al. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol Cancer Ther. 2014 Nov;13(11):2515-26. [Content Brief]
Keywords
