[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol

製品番号: HY-120654: Data Sheet 取扱説明書
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[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol (compound 13g) is a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. [1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol shows a potent apoptotic effect.

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[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol 構造式

CAS 番号 : 890854-82-7

容量	価格（税別）	在庫状況	数量
1 mg	$62	お問い合わせ 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
5 mg	$257	お問い合わせ 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	7 μM Compound: 13g	Antiproliferative activity against human HL60 cell line Antiproliferative activity against human HL60 cell line	[PMID: 16686543]
HL-60	IC₅₀	7 μM Compound: 14	Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method	[PMID: 19764793]
K562	IC₅₀	20 μM Compound: 1	Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method	[PMID: 25221651]
K562	IC₅₀	20 μM Compound: 13g	Antiproliferative activity against human K562 cell line expressing Bcr-Abl Antiproliferative activity against human K562 cell line expressing Bcr-Abl	[PMID: 16686543]
K562	IC₅₀	20 μM Compound: 14	Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method	[PMID: 19764793]
K562	IC₅₀	75 μM Compound: 14	Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay	[PMID: 19764793]
MDR	IC₅₀	23 μM Compound: 13g	Antiproliferative activity against MDR human HL60R cell line Antiproliferative activity against MDR human HL60R cell line	[PMID: 16686543]
U373-MAGI	EC₅₀	8.8 μM Compound: 6	Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay	[PMID: 23010273]

分子量

278.30

分子式

C₁₈H₁₄O₃

CAS 番号

890854-82-7

SMILES

OC1=CC=C(C2=CC=C(C3=CC(O)=CC(O)=C3)C=C2)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Marinella Roberti, et al. Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. [Content Brief]