[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol
[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol (compound 13g) is a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. [1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol shows a potent apoptotic effect.
For research use only. We do not sell to patients.
- CAS No.: 890854-82-7
- Formula: C18H14O3
- Molecular Weight:278.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
7 μM
Compound: 14
|
Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method
Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method
|
[PMID: 19764793] |
| HL-60 | IC50 |
7 μM
Compound: 13g
|
Antiproliferative activity against human HL60 cell line
Antiproliferative activity against human HL60 cell line
|
[PMID: 16686543] |
| K562 | IC50 |
20 μM
Compound: 1
|
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
|
[PMID: 25221651] |
| K562 | IC50 |
20 μM
Compound: 14
|
Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method
Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method
|
[PMID: 19764793] |
| K562 | IC50 |
20 μM
Compound: 13g
|
Antiproliferative activity against human K562 cell line expressing Bcr-Abl
Antiproliferative activity against human K562 cell line expressing Bcr-Abl
|
[PMID: 16686543] |
| K562 | IC50 |
75 μM
Compound: 14
|
Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay
Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay
|
[PMID: 19764793] |
| MDR | IC50 |
23 μM
Compound: 13g
|
Antiproliferative activity against MDR human HL60R cell line
Antiproliferative activity against MDR human HL60R cell line
|
[PMID: 16686543] |
| U373-MAGI | EC50 |
8.8 μM
Compound: 6
|
Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
|
[PMID: 23010273] |
Chemical Information
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CAS No. 890854-82-7
-
Molecular Weight 278.30
-
Formula C18H14O3
-
SMILES
OC1=CC=C(C2=CC=C(C3=CC(O)=CC(O)=C3)C=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)