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  3. (Rac)-Acolbifene

(Rac)-Acolbifene (Synonyms: EM-343; (Rac)-EM-652)

Cat. No.: HY-16023B
Handling Instructions

(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380.

For research use only. We do not sell to patients.

(Rac)-Acolbifene Chemical Structure

(Rac)-Acolbifene Chemical Structure

CAS No. : 151533-34-5

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Description

(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380[1].

In Vitro

(Rac)-Acolbifene (EM-343; (Rac)-EM-652)  shows a inhibitory effect in T-47D cells with an IC50 value of 0.110 nM[1].

Cell Viability Assay[1]

Cell Line: T-47D cells
Concentration: 0.110 nM
Incubation Time: 72 hours
Result: Inhibited T-47D cells growth.
In Vivo

(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice)[1].

Molecular Weight

457.56

Formula

C₂₉H₃₁NO₄

CAS No.

151533-34-5

SMILES

OC1=CC=C2C(C)=C(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)OC2=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

(Rac)-AcolbifeneEM-343(Rac)-EM-652EM343EM 343Estrogen Receptor/ERRracemicanti-estrogenicInhibitorinhibitorinhibit

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(Rac)-Acolbifene
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