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  2. Estrogen Receptor/ERR
  3. Nitromifene

Nitromifene (Synonyms: CI628)

Cat. No.: HY-100266
Handling Instructions

Nitromifene is an antagonist of estrogen receptor (ER).

For research use only. We do not sell to patients.

Nitromifene Chemical Structure

Nitromifene Chemical Structure

CAS No. : 10448-84-7

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Nitromifene is an antagonist of estrogen receptor (ER).

IC50 & Target


In Vitro

Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

MCF 7 cells are used in this study. The experiment is carried out in 6-well cluster plates. To each well is added 5 mL of a suspension of 2×105 cells in log phase growth. Medium is changed after 48 h and after 96 h, medium is replaced with 5 mL of serum-free medium containing 2 nM of the radioligand. Nitromifene is dissolved in DMSO (5 μL) to give final concentrations of 0, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM. Nonspecific binding is determined in incubations to which the radioinert counterpart of the radioligand is added at a concentration of 1 μM. Incubations are run in triplicate for 1 h at 37°C.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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