ER degrader 12
ER degrader 12 (Example 1) is an estrogen receptor (ER) degrader with IC50 values for ERα and ERβ of 2.3 and 80.2 nM respectively (TR-FRET experiment). ER degrader 12 inhibits the proliferation of MCF-7 cells, with an IC50 of 1.53 nM. ER degrader 12 can be used for research on breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2376991-14-7
- Formula: C26H32F3N5O
- Molecular Weight:487.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERα 2.3 nM (IC50) |
ERβ 80.2 nM (IC50) |
Chemical Information
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CAS No. 2376991-14-7
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Molecular Weight 487.56
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Formula C26H32F3N5O
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SMILES
FC1=C(C2C3=C(CC(C)N2CC(C)C)C4=C(N=NN4)C=C3)C(F)=CC(OCCN5CC(C5)CF)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ER degrader 12 Related Classifications
HY-176955 Related Classifications
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