2376991-14-7
2376991-14-7
Chemical Structure
ER degrader 12
- CAS No.: 2376991-14-7
- Formula:C26H32F3N5O
- Molecular Weight:487.56
InChIKey: ULVQILJKGKMCLC-UHFFFAOYSA-N
SMILES: FC1=C(C2C3=C(CC(C)N2CC(C)C)C4=C(N=NN4)C=C3)C(F)=CC(OCCN5CC(C5)CF)=C1
Biological Activity: ER degrader 12 (Example 1) is an estrogen receptor (ER) degrader with IC50 values for ERα and ERβ of 2.3 and 80.2 nM respectively (TR-FRET experiment). ER degrader 12 inhibits the proliferation of MCF-7 cells, with an IC50 of 1.53 nM. ER degrader 12 can be used for research on breast cancer[1].
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ER degrader 12 | ER degrader 12 (Example 1) is an estrogen receptor (ER) degrader with IC50 values for ERα and ERβ of 2.3 and 80.2 nM respectively (TR-FRET experiment). ER degrader 12 inhibits the proliferation of MCF-7 cells, with an IC50 of 1.53 nM. ER degrader 12 can be used for research on breast cancer. | |||||||||||||||||||||
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References
Keywords
