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Cat. No.: HY-155196

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ER degrader 6

ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER)α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness.

For research use only. We do not sell to patients.

CAS No.: 2922929-62-0
Formula: C₃₃H₃₄FN₃O₅SSe
Molecular Weight:682.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ER degrader 6 Chemical Structure

CAS No.: 2922929-62-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

ERα

All Estrogen Receptor/ERR Isoforms :

In Vitro

ER degrader 6 (compound 35s) exhibits antiproliferative and ERα degradation activity in multiple ERα-positive breast cancer (BC) cell lines bearing either wild-type or mutant ERα^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2922929-62-0
Molecular Weight 682.66
Formula C₃₃H₃₄FN₃O₅SSe
SMILES

O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11094-11117. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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ER degrader 6

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ER degrader 6 Related Classifications

HY-155196 Related Classifications