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Cat. No.: HY-15731S1

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Estetrol-d₄ (Major)

Estetrol-d₄ (Major) is the deuterium labeled Estetrol (HY-15731). Estetrol, an orally active estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol binds ERα as well as ERβ (with a fourfold lower affinity). Estetrol increases eNOS expression/activity and NO synthesis in endothelial cells. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast. Estetrol can be used in contraception and menopausal hormone research.

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CAS No.: 2734920-42-2
Formule: C₁₈H₂₀D₄O₄
Masse moléculaire:308.41

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (246 KB)

Estetrol-d₄ (Major) Chemical Structure

CAS No.: 2734920-42-2

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Activité biologique
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR :

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Voir tous les produits spécifiques à Isoform NO Synthase :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2734920-42-2
Unlabeled Cas 15183-37-6
Masse moléculaire 308.41
Formule C₁₈H₂₀D₄O₄
SMILES

[2H]C1=C(C([2H])=C(C2=C1)C([2H])(C[C@@]3([C@@]2(CC[C@]4([C@]3([C@H]([C@H]([C@@H]4O)O)O)[H])C)[H])[H])[2H])O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.