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Cat. No.: HY-170332

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PROTAC ER Degrader-15

PROTAC ER Degrader-15 (Compound 40) is an orally active degrader of the estrogen receptor (ER) with anticancer activity，which can be used in breast cancer research (Pink: Target Protein Ligand (HY-170334); Black: Linker (HY-30756); Blue: E3 Ligase Ligand (HY-138793); E3 Ligase Ligand-Linker Conjugate (HY-169979)).
(Pink: Estrogen Receptor/ERR ligand (HY-170334); Blue: Cereblon ligand (HY-138793); Black: linker (HY-30756)).

For research use only. We do not sell to patients.

Formula: C₄₇H₄₇F₄N₅O₅
Molecular Weight:837.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PROTAC ER Degrader-15 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC ER Degrader-15 (Compound 40) is an orally active degrader of the estrogen receptor (ER) with anticancer activity，which can be used in breast cancer research (Pink: Target Protein Ligand (HY-170334); Black: Linker (HY-30756); Blue: E3 Ligase Ligand (HY-138793); E3 Ligase Ligand-Linker Conjugate (HY-169979))^[1]. (Pink: Estrogen Receptor/ERR ligand (HY-170334); Blue: Cereblon ligand (HY-138793); Black: linker (HY-30756)).

All PROTACs Isoforms :

All Estrogen Receptor/ERR Isoforms :

Chemical Information

Molecular Weight 837.90
Formula C₄₇H₄₇F₄N₅O₅
SMILES

OC1=CC=C2C(OC[C@H](C3=C(F)C=CC=C3F)[C@@H]2C4=CC(F)=C(N5CCC(CN6CCC7(CN(C8=CC=C(C(N(C9C(NC(CC9)=O)=O)C%10)=O)C%10=C8)C7)CC6)CC5)C(F)=C4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Du wu, et al. Aromatic compound, method for preparing same, and use thereof in preparation of estrogen receptor degrader. Patent, WO2023241598, 2023-12-21.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PROTAC ER Degrader-15

All PROTACs Isoforms

All Estrogen Receptor/ERR Isoforms