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  3. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine

2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Synonyms: EM-12)

Cat. No.: HY-138793
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas.

For research use only. We do not sell to patients.

2-(2,6-Dioxopiperidin-3-yl)phthalimidine Chemical Structure

2-(2,6-Dioxopiperidin-3-yl)phthalimidine Chemical Structure

CAS No. : 26581-81-7

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Description

2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas[1][2].

In Vivo

Young male Sprague-Dawley rats in 3 groups are fed a basal diet supplemented with 0.10 wt. % each of thalidomide and its imide-analog of much higher teratogenicity, 2-(2,6-Dioxopiperidin-3-yl)phthalimidine. Following an induction period of 17 days on the diets, all animals are injected subcutaneously with 1,2-dimethylhydrazine at 20 mg/kg for a total of 20 weekly doses and killed on week 18 after the 20th injection. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine-fed group elicits statistically significant increases both in the total and ascending colon-based adenocarcinomas as compared with the control findings, in keeping with its greater teratogenicity and embryotoxicity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

244.25

Formula

C₁₃H₁₂N₂O₃

CAS No.
SMILES

O=C(C(N(CC1=C2C=CC=C1)C2=O)CC3)NC3=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

2-(2,6-Dioxopiperidin-3-yl)phthalimidineEM-12EM12EM 12OthersteratogenicanaloguestereoselectivecolonadenocarcinomasInhibitorinhibitorinhibit

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Product Name:
2-(2,6-Dioxopiperidin-3-yl)phthalimidine
Cat. No.:
HY-138793
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