2-(2,6-Dioxopiperidin-3-yl)phthalimidine
Based on 1 publication(s) in Google Scholar
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas.
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- Pureza : 98.08%
- No. CAS: 26581-81-7
- Fòrmula: C13H12N2O3
- Peso molecular:244.25
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-14658
Thalidomide -
HY-138793R
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Standard) -
HY-103609
Pyrene -
HY-153169
6PPD-Q -
HY-W127341
Phytanic acid methyl ester -
HY-W127566
Heptacosanoic acid -
HY-W679754
Pentacosafluorotridecanoic Acid -
![2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine](https://file.medchemexpress.com/product_pic/hy-w281364.gif)
HY-W281364
2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine -
HY-103609R
Pyrene (Standard) -
HY-W060216
N-Acetyl-DL-penicillamine -
HY-W127566R
Heptacosanoic acid (Standard) -
HY-W775354
1,2,3,4,7,8-Hexachlorodibenzofuran
Publications Citing Use of MedChemExpress (MCE) 2-(2,6-Dioxopiperidin-3-yl)phthalimidine
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Cereblon |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | CC50 |
>10 μM
Compound: EM12
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Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter Glo Luminescent cell viability assay
Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter Glo Luminescent cell viability assay
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[PMID: 37974938] |
Chemical Information
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No. CAS 26581-81-7
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Appearance Solid
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Peso molecular 244.25
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Fòrmula C13H12N2O3
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Color Off-white to gray
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SMILES
O=C(C(N(CC1=C2C=CC=C1)C2=O)CC3)NC3=O
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Synonyms
EM-12
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (511.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Merker HJ, et al. Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development. Arch Toxicol. 1988;61(3):165-179. [Content Brief]
[2]. Gershbein LL. The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. Cancer Lett. 1991;60(2):129-133. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0942 mL | 20.4708 mL | 40.9417 mL | 102.3541 mL |
| 5 mM | 0.8188 mL | 4.0942 mL | 8.1883 mL | 20.4708 mL | |
| 10 mM | 0.4094 mL | 2.0471 mL | 4.0942 mL | 10.2354 mL | |
| 15 mM | 0.2729 mL | 1.3647 mL | 2.7294 mL | 6.8236 mL | |
| 20 mM | 0.2047 mL | 1.0235 mL | 2.0471 mL | 5.1177 mL | |
| 25 mM | 0.1638 mL | 0.8188 mL | 1.6377 mL | 4.0942 mL | |
| 30 mM | 0.1365 mL | 0.6824 mL | 1.3647 mL | 3.4118 mL | |
| 40 mM | 0.1024 mL | 0.5118 mL | 1.0235 mL | 2.5589 mL | |
| 50 mM | 0.0819 mL | 0.4094 mL | 0.8188 mL | 2.0471 mL | |
| 60 mM | 0.0682 mL | 0.3412 mL | 0.6824 mL | 1.7059 mL | |
| 80 mM | 0.0512 mL | 0.2559 mL | 0.5118 mL | 1.2794 mL | |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0235 mL |
2-(2,6-Dioxopiperidin-3-yl)phthalimidine Related Classifications
HY-138793 Related Classifications
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