26581-81-7
26581-81-7
Chemical Structure
2-(2,6-Dioxopiperidin-3-yl)phthalimidine
Synonym(s): EM-12
- CAS No.: 26581-81-7
- Formula:C13H12N2O3
- Molecular Weight:244.25
IUPAC Name: 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChIKey: WENKGSGGXGQHSH-UHFFFAOYSA-N
SMILES: O=C(C(N(CC1=C2C=CC=C1)C2=O)CC3)NC3=O
Biological Activity: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas[1][2].
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine | 98.08% | 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. | ||||||||||||||||||||
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Standard) | ≥98% | 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Standard) is the analytical standard of 2-(2,6-Dioxopiperidin-3-yl)phthalimidine. This product is intended for research and analytical applications. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. | ||||||||||||||||||||
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References
- [1]. Merker HJ, et al. Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development. Arch Toxicol. 1988;61(3):165-179. [Content Brief]
- [2]. Gershbein LL. The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. Cancer Lett. 1991;60(2):129-133. [Content Brief]
